Specification of Multipotential cardiovascular progenitor cell during embryonic stem cell differentiation and embryonic development
Specification of Multipotential cardiovascular progenitor cell during embryonic stem cell differentiation and embryonic development
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DOI：
10.1016/j.tcm.2007.08.004
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发表时间：
2007-10-01
影响因子：
9.3
通讯作者：
Keller, Gordon M.
中科院分区：
文献类型：
--
作者：
Kattman, Steven J.;Adler, Eric D.;Keller, Gordon M.
完全形成的心脏由不同的细胞谱系组成，包括肌细胞、内皮细胞、血管平滑肌细胞和成纤维细胞，它们在胚胎发育期间来源于中胚层的不同亚群。谱系追踪研究的结果表明，心肌细胞从表达胎肝激酶-1的细胞发育而来，这表明心脏谱系可能来自具有血管心肌细胞潜能的祖细胞。最近使用胚胎干细胞模型的研究已经鉴定出一种显示血管和心肌细胞潜能的胎肝激酶-I（+）祖细胞。从早期小鼠胚胎中也分离出了类似的祖细胞。这些心血管祖细胞的鉴定和分离建立了一个新的心脏发育模型，将提供对心血管谱系多样化调节机制的见解。这些祖细胞也可能代表了一种新的细胞群，用于先天性心脏病模型和细胞替代疗法。（Trends Endovasc Med 2007; 17：240-246）（c）2007，Elsevier Inc.
The fully formed heart is composed of diverse cell lineages including myocytes, endothelial cells, vascular smooth muscle cells, and fibroblasts that derive from distinct subsets of mesoderm during embryonic development. Findings from lineage tracing studies indicate that cardiomyocytes develop from cells that express fetal liver kinase-1, suggesting that the cardiac lineages may arise from a progenitor cell with vascular cardiomyocytes potential. Recent studies using the embryonic stem cell model have led to the identification of a fetal liver kinase-l(+) progenitor cell that displays both vascular and cardiomyocyte potential. A comparable progenitor was also isolated from the early mouse embryo. Identification and isolation of these cardiovascular progenitor cells establishes a new model of heart development that will provide insights into the mechanisms regulating cardiovascular lineage diversification. These progenitor cells may also represent a novel cell population for models of congenital heart disease and cell replacement therapy. (Trends Cardiovasc Med 2007; 17:240-246) (c) 2007, Elsevier Inc.