Four-year prospective study of homosexual men: correlation of immunologic abnormalities, clinical status, and serology to human immunodeficiency virus.
Four-year prospective study of homosexual men: correlation of immunologic abnormalities, clinical status, and serology to human immunodeficiency virus.
复制标题
对男同性恋者的四年前瞻性研究：免疫异常、临床状态和血清学与人类免疫缺陷病毒的相关性。
DOI：
10.1093/infdis/155.4.789
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Saxinger,WC
中科院分区：
文献类型：
--
作者：
el-Sadr,W;Marmor,M;Zolla-Pazner,S;Stahl,RE;Lyden,R;William,D;D'Onofrio,S;Weiss,SH;Saxinger,WC
人类免疫缺陷病毒（HIV;以前称为HTLV-III/LAV）感染与许多其他感染性疾病一样，与广泛的疾病表现有关。一些感染HIV的个体仍然没有症状，而另一些人则出现了轻微的全身症状，严重的疾病体征或AIDS，如疾病控制中心（CDC，At-lanta，Ga）所定义的[1]。影响各种临床表现发展的因素在很大程度上仍然未知。为了阐明可能影响HIV感染临床结局的因素，我们对一组高危男性进行了前瞻性研究。我们在此报告40名随机选择的来自纽约市的同性恋男性，他们在四年的时间内（1981-1985）进行了研究，并在个体基础上进行了血清学、免疫学和临床评估。
Infection with human immunodeficiency virus (HIV; for-merly called HTLV-III/LAV), like many other infectious diseases, is associated with a wide spectrum of disease manifestations. Some individuals infected with HIV have remained asymptomatic, while others have developed mild constitutional symptoms, severe signs of disease, or AIDS, as defined by the Centers for Disease Control (CDC, At-lanta, Ga)[1]. The factors that influence the development of the various clinical manifestations remain largely un-known. To elucidate factors that may influence the clini-cal outcome of HIV infection, we initiated a prospective study of a group of men at high risk for acquiring this infection. We report here on 40 randomly selected, homo-sexual men from New York City, who were studied over a four-year period (1981-1985) and were evaluated sero-logically, immunologically, and clinically on an individual basis.