High-fat diet disrupts behavioral and molecular circadian rhythms in mice
High-fat diet disrupts behavioral and molecular circadian rhythms in mice
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DOI：
10.1016/j.cmet.2007.09.006
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发表时间：
2007-11-01
期刊：
影响因子：
29
通讯作者：
Bass, Joseph
中科院分区：
文献类型：
--
作者：
Kohsaka, Akira;Laposky, Aaron D.;Bass, Joseph
生物钟控制日常节律，协调多种行为和生理过程，包括活动、睡眠、进食和燃料动态平衡。最近的研究表明，核心分子时钟机制中的基因改变可以对外周和中枢代谢调节信号产生显著影响。许多新陈代谢系统也循环，并可能反过来影响时钟基因和昼夜节律系统的功能。然而，关于能量平衡的变化如何影响生物钟，人们知之甚少。在这里，我们表明，高脂肪饮食导致小鼠运动活动节律周期的变化，以及规范的生物钟基因、调节时钟转录因子的核受体和参与下丘脑、肝脏和脂肪组织燃料利用的时钟控制基因的表达和循环的变化。这些结果表明，高卡路里饮食的摄入改变了哺乳动物生物钟的功能。
The circadian clock programs daily rhythms and coordinates multiple behavioral and physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent studies indicate that genetic alteration in the core molecular clock machinery can have pronounced effects on both peripheral and central metabolic regulatory signals. Many metabolic systems also cycle and may in turn affect function of clock genes and circadian systems. However, little is known about how alterations in energy balance affect the clock. Here we show that a high-fat diet in mice leads to changes in the period of the locomotor activity rhythm and alterations in the expression and cycling of canonical circadian clock genes, nuclear receptors that regulate clock transcription factors, and clock-controlled genes involved in fuel utilization in the hypothalamus, liver, and adipose tissue. These results indicate that consumption of a high-calorie diet alters the function of the mammalian circadian clock.