A population study of neutering status as a risk factor for canine prostate cancer
A population study of neutering status as a risk factor for canine prostate cancer
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DOI：
10.1002/pros.20590
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发表时间：
2007-08-01
期刊：
影响因子：
2.8
通讯作者：
Caldwell, Charles W.
中科院分区：
文献类型：
--
作者：
Bryan, Jeffrey N.;Keeler, Matthew R.;Caldwell, Charles W.
背景。据报道，在几个病例系列中，绝育的雄性狗比未绝育的雄性狗更容易患前列腺癌。这项研究是为了在大型人口数据库中评估前列腺癌的风险。该假设是，阉割是雄性伴侣犬患前列腺癌的危险因素。方法。数据来自对北美兽医教学医院的访问记录。查询兽医医学数据库 (VMDB)，发现患有膀胱移行细胞癌 (TCC)、前列腺腺癌 (ACA)、前列腺 TCC、前列腺癌 (CA) 和前列腺肿瘤的雄性狗。第二个查询显示所有 4 岁以上的雄性狗均未诊断出患有尿路癌。对这些人群进行比较，以确定与绝育状态相关的单独和集体罹患每种疾病的相对风险。计算品种的优势比作为风险因素。结果。绝育的雄性患各种癌症的风险显着增加。绝育男性膀胱 TCC 的优势比为 3.56 (3.02-4.21)，前列腺 TCC 为 8.00 (5.60-11.42)，前列腺腺癌为 2.12 (1.80-2.49)，前列腺癌为 3.86 (3.13-4.16)，前列腺癌为 2.84 (2.57-3.14)。所有前列腺癌。当病例仅限于组织学确诊的病例时，相对风险非常相似。结论。品种倾向表明遗传因素在前列腺癌的发展中发挥作用。 TCC 与绝育相关的风险最高，这支持了之前的研究，确定尿路上皮和导管上皮而不是腺泡上皮是这些肿瘤的来源。前列腺 67：1174-1181，2007 年。(c) 2007 Wiley-Liss, Inc.
BACKGROUND. Prostate cancer has been reported to occur more commonly in neutered than intact male dogs in several case series. This study was undertaken to evaluate risk of prostate cancer in a large population database. The hypothesis was that castration is a risk factor for prostate cancer in male companion dogs. METHODS. Data were derived from recorded visits to North American veterinary teaching hospitals. The Veterinary Medical Databases (VMDB) were queried to yield male dogs with urinary bladder transitional cell carcinoma (TCC), prostate adenocarcinoma (ACA), prostate TCC, prostate carcinoma (CA), and prostate tumors. A second query yielded all male dogs over the age of 4 years without a diagnosis of urinary tract cancer. These populations were compared to determine relative risks for developing each disease, singly and collectively, associated with neutering status. Odds ratios were calculated for breed as a risk factor. RESULTS. Neutered males had a significantly increased risk for each form of cancer. Neutered males had an odds ratio of 3.56 (3.02-4.21) for urinary bladder TCC, 8.00 (5.60-11.42) for prostate TCC, 2.12 (1.80-2.49) for prostate adenocarcinoma, 3.86 (3.13-4.16) for prostate carcinoma, and 2.84 (2.57-3.14) for all prostate cancers. Relative risks were highly similar when cases were limited to those with a histologically confirmed diagnosis. CONCLUSIONS. Breed predisposition suggests that genetic factors play a role in the development of prostate cancer. The risk associated with being neutered is highest for TCC, supporting previous work identifying the urothelium and ductular rather than acinar epithelium as the source of these tumors. Prostate 67: 1174-1181, 2007. (c) 2007 Wiley-Liss, Inc.