Comparison of injectable calcium phosphate bone cement grafting and open flap debridement in periodontal intrabony defects: A randomized clinical trial
Comparison of injectable calcium phosphate bone cement grafting and open flap debridement in periodontal intrabony defects: A randomized clinical trial
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DOI：
10.1902/jop.2008.070141
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发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Izumi, Yuichi
中科院分区：
文献类型：
--
作者：
Shirakata, Yoshinori;Setoguchi, Takashi;Izumi, Yuichi
背景：牙周治疗的最终目的是使缺损的牙周组织再生。骨移植、引导组织再生和应用生长因子用于牙周再生。本研究旨在评价一种新的可注射磷酸钙骨水泥（CPC）在人牙周骨内defects.Methods：30例（平均年龄53.4 +/- 9.1岁）牙周炎和狭窄骨内缺损的临床疗效。受试者被随机分为CPC移植组（N = 15）或单纯开放皮瓣清创术（OFD）组（N = 15）。在基线和3、6、9和12个月时进行临床测量;在基线、术后2周、6和12个月时拍摄X线片。结果：CPC组6例在术后12个月内CPC暴露或脱落，其余9例（CPC-R组）未出现感染或化脓等不良反应。总体而言，与基线值相比，CPC-R和OFD治疗组在3、6、9和12个月时的探查深度显著降低，临床附着水平显著增加。然而，两组之间的任何临床参数均无显著差异。在CPC-R组，影像学骨水平增益似乎是大于OFD group.Conclusions：本研究未能证明任何上级的临床结果相比，OFD组CPC组，但是，X光片显示更有利的结果在CPC-R组。CPC的充填量和硬度可能影响牙周骨下缺损的临床疗效。
Background: Regeneration of lost periodontium is the ultimate goal of periodontal therapy. Bone grafts, guided tissue regeneration, and application of growth factors are used for periodontal regeneration. This study aimed to evaluate the clinical efficacy of a new, injectable calcium phosphate bone cement (CPC) in human periodontal intrabony defects.Methods: Thirty subjects (mean age, 53.4 +/- 9.1 years) with periodontitis and narrow intrabony defects were enrolled in the study. Subjects were classified randomly into the CPC graft group (N = 15) or the open flap debridement (OFD) alone group (N = 15). Clinical measurements were performed at baseline and at 3, 6, 9, and 12 months; radiographs were taken at baseline, 2 weeks, and 6 and 12 months after surgery. The Student t test was used for statistical analysis.Results: In the CPC group, six cases showed exposure or loss of the CPC within 12 months, whereas the remaining nine cases (CPC-R group) showed no adverse reaction, including infection or suppuration. Overall, CPC-R and OFD treatment groups exhibited a significant reduction in probing depth and a significant gain in clinical attachment level at 3, 6, 9, and 12 months compared to baseline values. However, there were no significant differences in any of the clinical parameters between the groups. In the CPC-R group, radiographic bone level gain appeared to be greater than in the OFD group.Conclusions: The present study failed to demonstrate any superior clinical outcomes for the CPC group compared to the OFD group; however, radiographs revealed more favorable results in the CPC-R group. The filling volume and stiffness of CPC may compromise the clinical outcomes for periodontal intrabony defects.