Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma.
Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma.
复制标题
DOI：
--
复制
发表时间：
2005-02
期刊：
影响因子：
--
通讯作者：
Y. Uchikado;S. Natsugoe;H. Okumura;T. Setoyama;M. Matsumoto;S. Ishigami;T. Aikou
中科院分区：
文献类型：
--
作者：
Y. Uchikado;S. Natsugoe;H. Okumura;T. Setoyama;M. Matsumoto;S. Ishigami;T. Aikou
目的探讨E-钙粘蛋白（E-cadherin）在食管鳞癌发生、发展及转移中的作用。Slug是一种新发现的E-cadherin抑制性转录因子，属于snail转录因子家族。本研究旨在探讨E-cadherin和Slug在食管鳞癌中的表达及其临床意义。实验设计应用免疫组织化学方法检测203例食管鳞癌组织中E-cadherin和Slug蛋白的表达。分析这些蛋白的表达与临床病理因素，包括预后之间的关系。结果E-cadherin和Slug在乳腺癌组织中的阳性表达率分别为43%和48%。E-cadherin表达降低或Slug表达阳性的肿瘤比E-cadherin表达保留或Slug表达阴性的肿瘤浸润更深、有更多的淋巴结转移和更多的淋巴管浸润。Slug表达与E-cadherin表达降低显著相关。在Slug阳性表达的98例肿瘤中，67例（68.4%）E-cadherin表达降低（P = 0.0011）。E-cadherin表达降低或Slug表达阳性的患者临床结局较差。在保留E-cadherin组中，Slug表达阴性的患者的5年生存率高于Slug表达阳性的患者（P = 0.035）。多因素分析显示E-cadherin和Slug表达不是独立的预后因素。结论评价E-cadherin的表达及E-cadherin与Slug的共表达对预测ESCC的恶性性质有一定的参考价值。
PURPOSE The expression of E-cadherin correlates with the development, progression, and metastasis of esophageal squamous cell carcinoma (ESCC). Slug, a member of the snail family of transcriptional factors, is a newly identified suppressive transcriptional factor of E-cadherin. The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC. EXPERIMENTAL DESIGN Immunohistochemistry was used to investigate the expression of E-cadherin and Slug proteins in 203 patients with ESCC. The relationships between expression of these proteins and clinicopathologic factors, including prognosis, were analyzed. RESULTS Positive expression of E-cadherin and Slug was observed in 43% and 48% of cases, respectively. The tumors with reduced E-cadherin expression or positive Slug expression invaded deeper, had more lymph node metastasis, and had more lymphatic invasion than the tumors with preserved E-cadherin expression or negative Slug expression. Slug expression significantly correlated with reduced E-cadherin expression. Sixty-seven of the 98 (68.4%) tumors with positive Slug expression had reduced E-cadherin expression (P = 0.0011). Patients with reduced E-cadherin expression or positive Slug expression had poor clinical outcomes. In the preserved E-cadherin group, the 5-year survival rate was better for patients who were negative for Slug expression than for those who were positive for Slug expression (P = 0.035). Multivariate analysis indicated that E-cadherin expression and Slug expression were not independent prognostic factors. CONCLUSIONS Evaluation of not only the expression of E-cadherin but also the co-expression of E-cadherin and Slug in preserved E-cadherin group is useful for predicting malignant properties of ESCC.