A novel phantom model for mouse tumor dose assessment under MV beams.
A novel phantom model for mouse tumor dose assessment under MV beams.
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DOI：
10.1097/hp.0b013e31821a4838
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发表时间：
2011-12
期刊：
影响因子：
2.2
通讯作者：
Claudio P
中科院分区：
文献类型：
--
作者：
Gossman MS;Das IJ;Sharma SC;Lopez JP;Howard CM;Claudio P
为了在进行活体小鼠放射生物学研究之前准确确定小鼠的剂量，构建了组织等效的荷瘤模型小鼠并钻孔以容纳探测器。对四种不同类型的辐射探测器进行了比较，每种探测器都插入模型小鼠中，在 6 MV 线性加速器光束下进行辐射测量。使用二极管、热释光剂量计、金属氧化物半导体场效应晶体管的剂量检测响应，并将其与参考针点电离室的剂量检测响应进行比较。同样，还直接比较了计算机化治疗计划系统。每个检测器系统显示的结果与治疗计划系统计算的剂量相似，但也注意到一些差异。在 200-400 cGy 范围内，加速器校准输出剂量处方的平均偏差为：二极管为 -0.4% ± 0.5σ，TLD 为 -2.4% ± 2.6σ，MOSFET 为 -2.9% ± 5.0σ，治疗计划系统为 +1.3% ± 1.4σ。这种模型小鼠设计独特、简单、可重复，因此推荐作为通过本研究中使用的任何探测器进行放射生物学小鼠研究的剂量测定的标准方法。我们完全主张在基于直线加速器的剂量输送之前尽可能建立治疗计划模型。
In order to determine a mouse’s dose accurately and prior to engaging in live mouse radiobiological research, a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. Comparisons were made between four different types of radiation detectors, each inserted into the phantom mouse for radiation measurement under a 6 MV linear accelerator beam. Dose detection response from a diode, thermoluminescent dosimeters, metal-oxide semiconductor field-effect transistors were used and compared to that of a reference pin-point ionization chamber. Likewise, a computerized treatment planning system was also directly compared. Each detector system demonstrated results similar to the dose computed by the therapeutic treatment planning system, although some differences were noted. The average disagreement from a accelerator calibrated output dose prescription in the range of 200–400 cGy were −0.4% ± 0.5σ for the diode, −2.4% ± 2.6σ for the TLD, −2.9% ± 5.0σ for the MOSFET and +1.3% ± 1.4σ for the treatment planning system. This phantom mouse design is unique, simple, reproducible and therefore recommended as a standard approach to dosimetry for radiobiological mouse studies by means of any of the detectors used in this study. We fully advocate for treatment planning modeling when possible prior to linac-based dose delivery.