CMOS Integrated DNA Microarray Based on GMR Sensors
CMOS Integrated DNA Microarray Based on GMR Sensors
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DOI：
10.1109/iedm.2006.346887
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发表时间：
2006-12
期刊：
影响因子：
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通讯作者：
Shu-Jen Han;Liang Xu;Heng Yu;R. Wilson;R.L. White;N. Pourmand;S.X. Wang
中科院分区：
文献类型：
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作者：
Shu-Jen Han;Liang Xu;Heng Yu;R. Wilson;R.L. White;N. Pourmand;S.X. Wang
将高密度GMR传感器阵列与标准芯片集成，用于DNA杂交检测。杂化DNA对磁性纳米颗粒的吸收改变了传感器的电阻，产生的电信号通过芯片上的电路直接测量。通过不同的表面修饰，该芯片还可以应用于其他生物反应检测，如蛋白质分析
A high density GMR sensor array was integrated with a standard CMOS chip for DNA hybridization detection. Absorption of magnetic nanoparticles by the hybridized DNA alters the sensor resistance, and generated electrical signals are directly measured with the on-die circuitry. The proposed biochip can be applied to other bio-reaction detection, e.g. protein assay, through different surface modifications