Stromal vascular fraction (SVF) cells enhance long-term survival of autologous fat grafting through the facilitation of M2 macrophages
Stromal vascular fraction (SVF) cells enhance long-term survival of autologous fat grafting through the facilitation of M2 macrophages
复制标题
基质血管成分 (SVF) 细胞通过促进 M2 巨噬细胞增强自体脂肪移植的长期存活
DOI：
10.1002/cbin.10099
复制
发表时间：
2013-08-01
影响因子：
3.9
通讯作者：
Lu, Feng
中科院分区：
文献类型：
--
作者：
Dong, Ziqing;Fu, Rong;Lu, Feng
最佳的血流灌注可能是自体脂肪组织运输耐受性和存活率的关键。间质血管分数(SVF)细胞治疗可以通过促进血管生成来显著提高脂肪移植物的存活率。然而，在SVF辅助的脂肪组织移植的后期阶段，SVF细胞的保存率很低。因此，它很难定义通过长期运输的血管生成效应。脂肪组织在运输的早期遭受急性缺氧，导致巨噬细胞的募集。M2巨噬细胞通过作为血管生成信号源，促进TIP细胞迁移，促进TIP细胞融合，促进脂肪移植中的血管生成。此外，M2巨噬细胞在移植物中产生的血管生成和抗炎微环境可能刺激浸润性巨噬细胞向M2巨噬细胞转化。这些M2巨噬细胞可能通过血管生成增强移植物的长期滞留。基于这些观察，我们推测SVF细胞的长期血管生成效应可能是通过促进M2巨噬细胞实现的。
Optimum perfusion may be the key to the endurance, and hence survival, of autologous adipose tissue transportation. Stromal vascular fraction (SVF) cell therapy can greatly improve the survival of fat grafts by enhancing angiogenesis. However, SVF cells are poorly retained in later stages of SVF-assisted adipose tissue transplant. Therefore, it hardly defines the angiogenic effect through long-term transportation. Adipose tissue suffers from acute hypoxia in the early stage of transportation, leading to the recruitment of macrophages. M2 macrophages enhance angiogenesis in adipose transplantation by acting as an angiogenic signal source, promoting tip cell migration and assisting tip cell fusion. Furthermore, the angiogenic and anti-inflammatory micro-environment in the graft created by M2 macrophages may stimulate the transformation of infiltrating macrophages to M2 macrophages. These M2 macrophages may enhance the long-term retention of graft through angiogenesis. Based on these observations, we postulate that the long-term angiogenic effect of SVF cells may be achieved through the facilitation of the M2 macrophages.