DNA nanotechnology technique for monodisperse synthesis
DNA nanotechnology technique for monodisperse synthesis
复制标题
DOI：
10.1021/ma061405s
复制
发表时间：
2006-12-26
期刊：
影响因子：
5.5
通讯作者：
Pickett, Galen T.
中科院分区：
文献类型：
--
作者：
Pickett, Galen T.
我考虑从末端用 DNA 配体标记的小单分散链开始合成高分子量单分散聚合物。当这些配体被适当设计时，两阶段混合方案会产生两倍于原始分子量的链溶液。可以重复该过程以产生越来越大的链，其具有基本上生物学上精确的分子量。在协议的轻微概括下，精密支化、二嵌段、三嵌段和多嵌段共聚物的设计是可能的。
I consider the synthesis of high molecular weight, monodisperse polymers starting from small, monodisperse chains end-labeled with DNA ligands. When these ligands are appropriately designed, a two-stage mixing protocol results in a solution of chains of twice the original molecular weight. The process can be repeated to produce larger and larger chains, of essentially biologically precise molecular weights. The design of precision branched, di-, tri-, and multiblock copolymers is possible under a slight generalization of protocol.