Visual receptive fields of striate cortex neurons in awake monkeys.
Visual receptive fields of striate cortex neurons in awake monkeys.
复制标题
清醒猴子纹状皮层神经元的视觉感受野。
DOI：
10.1152/jn.1969.32.5.727
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发表时间：
1969
影响因子：
2.5
通讯作者：
R. Wurtz
中科院分区：
文献类型：
--
作者：
R. Wurtz
Lettvin 及其同事 (25) 以及 Hubel 和 Wiesel (19) 的实验表明，脊椎动物视觉系统中的神经元对视觉刺激的特定特征敏感。这些特征被称为刺激的“触发特征”(3)，包括大小、形状、方向、颜色以及运动的速率和方向等因素；刺激有效的视野区域称为神经元的感受野 (17)。随后在多种动物中确定了视觉系统神经元的感受野特征（参考文献参见 7、16）。此外，Hubel 和 Wiesel (19-24, 30) 还表明，在视觉系统的连续较高级别激活神经元所需的刺激特征会发生变化。在猫和猴子中，他们观察到感受野的主要类型逐渐变化，从视网膜神经节和外侧膝状体细胞的圆形感受野，到最简单的皮质细胞的拉长感受野，再到其他皮质神经元的更复杂的感受野。对视觉系统的这种理解完全来自动物被麻痹并且经常被麻醉的实验。此类手术旨在消除所有眼球运动，特别是正常视力特征的生理性眼球震颤的小眼球运动 (1)。本实验的目的是确定清醒、行为动物的纹状皮层神经元的感受野是否与麻醉状态下的相似。
THE EXPERIMENTS of Lettvin and colleagues (25) and Hubel and Wiesel (19) have indicated that a neuron in the vertebrate visual system is sensitive to particular characteristics of the visual stimulus. These characteristics have been referred to as the “trigger features” of the stimulus (3) and include such factors as size, shape, orientation, color, and rate and direction of movement; the area of the visual field over which the stimulus is effective is referred to as the receptive field of the neuron (17). Receptive-field characteristics of visual system neurons have subsequently been determined in a wide range of animals (for references see 7, 16). In addition, Hubel and Wiesel (19-24, 30) have shown that there are changes in the characteristics of the stimulus needed to activate a neuron at successively higher levels of the visual system. In both cats and monkeys they observed a progressive change in the predominant type of receptive field from the circular receptive fields of retinal ganglion and lateral geniculate cells, through the elongated receptive fields of the simplest cortical cells, to the more complex fields of other cortical neurons. This understanding of the visual system has been derived entirely from experiments in which the animal was paralyzed and frequently also anesthetized. Such procedures have been designed to eliminate all eye movements, particularly the small eye movements of physiological nystagmus that are characteristic of normal vision (1). The purpose of the present experiments was to determine whether receptive fields of striate cortex neurons in the awake, behaving animal are similar to those in the anesthetized,