A UNIFIED MODEL OF EUKARYOTIC CHROMOSOMES
A UNIFIED MODEL OF EUKARYOTIC CHROMOSOMES
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DOI：
10.1002/cyto.990110104
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
CHEN, TL
中科院分区：
文献类型：
--
作者：
MANUELIDIS, L;CHEN, TL
提出了 DNA 包装到染色体中的修订模型。其特征与观察到的结构尺寸以及与转录、复制和基质附着域相关的分子周期性一致。简单地解释了常色、异色和中期状态之间的转变。讨论了染色体带的分子和物理特性及其与特定 DNA 序列基序的相关性。
A revised model of DNA packaging into chromosomes is presented. Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains. The transitions between euchromatic, heterochromatic and metaphase states are explained simply. Molecular and physical properties of chromosomal bands, and their correlation with specific DNA sequence motifs are discussed.