Patterns of circulating gonadotropins and ovarian steroids during the first periovulatory period in the developing sheep.
Patterns of circulating gonadotropins and ovarian steroids during the first periovulatory period in the developing sheep.
复制标题
发育中的绵羊第一个围排卵期循环促性腺激素和卵巢类固醇的模式。
DOI：
10.1095/biolreprod45.3.471
复制
发表时间：
1991
影响因子：
3.6
通讯作者：
D. Foster
中科院分区：
文献类型：
--
作者：
K. Ryan;R. Goodman;F. Karsch;S. Legan;D. Foster
该报告提供的证据表明，绵羊青春期血清促性腺激素水平增加，这反映了该物种在第一次排卵时达到顶峰的关键激素事件。在预期青春期（32周龄）前后大约2个月的时间内，每隔4小时从6只雌性羔羊身上采集血样，直到观察到发情行为并通过血清黄体酮测定来验证排卵。对每只羔羊在青春期前后的循环 LH、FSH、孕酮和雌二醇浓度模式进行了表征。 LH 和 FSH 的血清水平在第一次排卵前促性腺激素激增之前大约 7-10 天开始上升。尽管促性腺激素水平在几天内逐渐增加，但血清雌二醇水平仅在促性腺激素激增前的最后 40-60 小时内上升。然而，血清孕酮曲线显示，由于第一次激增，6 名女性中只有 2 名诱导了正常（14-16 天）黄体期。在四只羔羊中，出现了持续 2.5 天的短暂黄体期，随后雌二醇再次升高和排卵前激增，然后导致持续 14 天的完整黄体期。这些数据清楚地表明，雌性绵羊青春期的诱发事件是循环促性腺激素水平的增加，并且新刺激的卵泡分泌的雌二醇为第一次排卵前激增提供了信号。
This report provides evidence that an increment in serum gonadotropin levels occurs at puberty in the sheep and that this reflects the critical hormonal event culminating in first ovulation in this species. Blood samples were collected from 6 female lambs at 4-h intervals for a period of approximately 2 mo around the expected time of puberty (32 wk of age) until behavioral estrus was observed and ovulation was verified by assay of serum progesterone. Patterns of circulating LH, FSH, progesterone, and estradiol concentrations were characterized during the peripubertal period for each lamb. A rise in serum levels of both LH and FSH began approximately 7-10 days before the first preovulatory surge of gonadotropins. Although the increase in gonadotropin levels occurred gradually over several days, serum estradiol levels rose only during the final 40-60 h prior to the preovulatory surge of gonadotropin. Serum progesterone profiles revealed, however, that normal (14-16-day) luteal phases were induced in only 2 of 6 females as a result of the first surge. In four lambs, a short luteal phase of 2.5 days' duration occurred, which was followed by another estradiol rise and a preovulatory surge that then resulted in a full luteal phase of 14 days' duration. These data demonstrate clearly that the precipitating event at puberty in the female sheep is an increase in circulating gonadotropin levels and that the estradiol secreted from the newly stimulated follicle provides the signal for the first preovulatory surge.
登录
查看更多内容
影响因子：
3.6
作者：
R. Goodman;S. Legan;K. Ryan;D. Foster;F. Karsch
通讯作者：
R. Goodman;S. Legan;K. Ryan;D. Foster;F. Karsch
促性腺激素和黄体酮在确定母羊排卵前雌二醇升高中的作用。
影响因子：
3.6
作者：
Goodman,RL;ReichertJr,LE;Legan,SJ;Ryan,KD;Foster,DL;Karsch,FJ
通讯作者：
Karsch,FJ
青春期前雌性绵羊的排卵前促性腺激素激增系统对雌二醇的刺激反馈作用极其敏感。
影响因子：
4.8
作者：
Foster,DL
通讯作者：
Foster,DL
猕猴卵巢对卵泡刺激素 (FSH) 和黄体生成素的脉冲输注的反应：成熟卵泡对 FSH 的敏感性增加。
影响因子：
4.8
作者：
Zeleznik,AJ;Kubik,CJ
通讯作者：
Kubik,CJ
青春期雌性恒河猴黄体生成激素分泌模式的发育变化：性腺完整和卵巢切除动物之间的比较。
影响因子：
4.8
作者：
Terasawa,E;Bridson,WE;Nass,TE;Noonan,JJ;Dierschke,DJ
通讯作者：
Dierschke,DJ