PEA3 is a nuclear target for transcription activation by non‐nuclear oncogenes.
PEA3 is a nuclear target for transcription activation by non‐nuclear oncogenes.
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PEA3 是非核癌基因转录激活的核靶标。
作者：
C. Wasylyk;P. Flores;A. Gutman;Bohdan Wasylyk
我们发现，转录因子PEA3的活性受非核癌基因表达的调节。该因子虽然不同于PEA1(AP1)，但被相同的癌基因(v-src、多瘤(Py)、中间T、c-Ha-ras、v-mos、v-raf)、十四酰佛波醇醋酸酯(TPA)和血清成分激活。我们提出的证据表明，PEA3和PEA1在多瘤病毒(Py)阿尔法域对癌基因表达的反应中协同作用。然而，与PEA1相反，c-fos似乎不是激活PEA3所必需的，这表明PEA3是非核癌基因调控转录的FOS独立靶点。
We have found that the activity of the transcription factor PEA3 is regulated by the expression of non‐nuclear oncogenes. This factor, although distinct from PEA1 (AP1), is activated by the same oncogenes (v‐src, polyoma (Py) middle T, c‐Ha‐ras, v‐mos, v‐raf), by tetradecanoyl phorbol‐acetate (TPA) and by serum components. We present evidence that PEA3 and PEA1 co‐operate in the response of the polyoma virus (Py) alpha domain to oncogene expression. However, in contrast to PEA1, c‐fos does not appear to be necessary for activation of PEA3, suggesting that PEA3 is a fos independent target for regulation of transcription by non‐nuclear oncogenes.