Genetic diversity of the 2013-14 human isolates of influenza H7N9 in China.
Genetic diversity of the 2013-14 human isolates of influenza H7N9 in China.
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DOI：
10.1186/s12879-015-0829-8
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发表时间：
2015-02-28
影响因子：
3.7
通讯作者：
Kelvin DJ
中科院分区：
文献类型：
--
作者：
Farooqui A;Leon AJ;Huang L;Wu S;Cai Y;Lin P;Chen W;Fang X;Zeng T;Liu Y;Zhang L;Su T;Chen W;Ghedin E;Zhu H;Guan Y;Kelvin DJ
H7N9 流感已成为中国的地方性病原体，在野生鸟类和家禽中广泛发现传播病毒。 2013年和2014年，中国东部和中南地区发生了两波人感染H7N9流感。在这项研究中，我们报告了第二波H7N9流感期间发生在广东省汕头市的前四例人感染H7N9流感病例，以及随后对病毒分离株的分析。对病毒基因组进行多片段扩增并在 Illumina MiSeq 中进行测序。随后，对 H7N9 流感病毒进行了系统发育分析，以确定该疾病在人类中的进化背景。汕头分离株的序列与主要东部 H7N9 集群（类似于 A/上海/1/2013 (H7N9)）比与南部 H7N9 集群（类似于 A/广东/1/2013 (H7N9)）更接近。目前，H7N9 流感有两个不同的系统发育群在中国流行，并由于禽类疾病的跨物种溢出而导致人类感染。东部群包括来自汕头的四个分离株，具有广泛的地理分布，并与南部群的流通范围更有限的区域重叠。持续监测禽类疾病对于更好地了解和预测人类病例的流行病学行为至关重要。本文的在线版本 (doi:10.1186/s12879-015-0829-8) 包含补充材料，可供授权用户使用。
Influenza H7N9 has become an endemic pathogen in China where circulating virus is found extensively in wild birds and domestic poultry. Two epidemic waves of Human H7N9 infections have taken place in Eastern and South Central China during the years of 2013 and 2014. In this study, we report on the first four human cases of influenza H7N9 in Shantou, Guangdong province, which occurred during the second H7N9 wave, and the subsequent analysis of the viral isolates. Viral genomes were subjected to multisegment amplification and sequenced in an Illumina MiSeq. Later, phylogenetic analyses of influenza H7N9 viruses were performed to establish the evolutionary context of the disease in humans. The sequences of the isolates from Shantou have closer evolutionary proximity to the predominant Eastern H7N9 cluster (similar to A/Shanghai/1/2013 (H7N9)) than to the Southern H7N9 cluster (similar to A/Guangdong/1/2013 (H7N9)). Two distinct phylogenetic groups of influenza H7N9 circulate currently in China and cause infections in humans as a consequence of cross-species spillover from the avian disease. The Eastern cluster, which includes the four isolates from Shantou, presents a wide geographic distribution and overlaps with the more restricted area of circulation of the Southern cluster. Continued monitoring of the avian disease is of critical importance to better understand and predict the epidemiological behaviour of the human cases. The online version of this article (doi:10.1186/s12879-015-0829-8) contains supplementary material, which is available to authorized users.
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