Human temporal lobe potentials in verbal learning and memory processes
Human temporal lobe potentials in verbal learning and memory processes
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DOI：
10.1016/s0028-3932(96)00110-8
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发表时间：
1997-05-01
期刊：
影响因子：
2.6
通讯作者：
Heinze, HJ
中科院分区：
文献类型：
--
作者：
Elger, CE;Grunwald, T;Heinze, HJ
动物实验和损伤研究已经表明颞叶结构对语言和记忆的重要性。我们记录了26例颞叶癫痫患者接受术前评估时，从人类颞叶外侧和内侧的颅内认知电位，使用单词和图片识别范例。神经心理学测试包括词汇流畅性、语言推理、持续注意力和语言学习记忆测试（VLMT），这是Rey听觉语言学习测试的改编版本。词特异性N400电位引起的中颞回的优势左半球（LTL-N400）预测学习后立即回忆的性能，而N400，引起的话，但不是图片在左前内侧颞叶（AMTL-N400），预测延迟回忆。在30分钟的延迟后，学习但忘记的单词数量仅与左前内侧颞叶中的单词引起的N400相关。因此，颅内记录表明，不同颞叶结构的不同电生理反应与特定神经心理学测试的记忆分数有关。(C)1997年爱思唯尔科学有限公司
Animal experiments and lesion studies have shown the importance of temporal lobe structures for language and memory. We recorded intracranial cognitive potentials from the human lateral and medial temporal lobe in 26 patients with temporal lobe epilepsy undergoing presurgical evaluation, using a word- and a picture-recognition paradigm. Neuropsychological testing included word fluency, verbal reasoning, sustained attention and a verbal learning memory test (VLMT), which was an adapted version of the Rey auditory verbal learning test. Word-specific N400-potentials elicited in the middle temporal gyrus of the dominant left hemisphere (LTL-N400) predicted immediate recall performance after learning, whereas N400s, elicited by words but not pictures in the left anterior medial temporal Lobe (AMTL-N400), predicted delayed recall. The number of words that were learned but forgotten after a 30-min delay correlated only with N400s elicited by words in the left anterior medial temporal lobe. Thus, intracranial recordings indicated that different electrophysiological responses in different temporal lobe structures were linked to memory scores from specific neuropsychological tests. (C) 1997 Elsevier Science Ltd.