Pathophysiological roles of ASK1-MAP kinase signaling pathways.
Pathophysiological roles of ASK1-MAP kinase signaling pathways.
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DOI：
10.5483/bmbrep.2007.40.1.001
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发表时间：
2007-01
期刊：
影响因子：
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通讯作者：
H. Nagai;T. Noguchi;K. Takeda;H. Ichijo
中科院分区：
文献类型：
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作者：
H. Nagai;T. Noguchi;K. Takeda;H. Ichijo
凋亡信号调节激酶1（Apoptosis signal-regulating kinase 1，ASK 1）是一种丝裂原活化蛋白激酶（mitogenactivated protein kinase，MAPK），可激活JNK和p38激酶。ASK 1被各种应激激活，如活性氧（ROS）、内质网（ER）应激、脂多糖（LPS）和钙内流，这些应激被认为是导致各种人类疾病的发病机制或恶化的原因。最近的研究表明，ASK 1参与ROS或ER应激相关疾病，这表明ASK 1可能是各种人类疾病的潜在治疗靶点。在这篇综述中，我们重点关注发病机制与ASK 1-MAPK途径之间关系的最新发现。
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.