Predicting factors of interstitial lung disease in dermatomyositis and polymyositis
Predicting factors of interstitial lung disease in dermatomyositis and polymyositis
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DOI：
10.2340/00015555-0177
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Shen, Jui-Lung
中科院分区：
文献类型：
--
作者：
Chen, Yi-Ju;Wu, Chun-Ying;Shen, Jui-Lung
本研究的目的是确定皮肌炎/多发性肌炎患者间质性肺疾病的预测因素并评估其预后。1995-2005年，我们回顾性分析了56例确诊为皮肌炎和多发性肌炎的患者的临床资料和实验室资料。肺间质性疾病在这些患者中很常见（41.9%）。呼吸困难和咳嗽是两种最常见的最初表现。抗jol抗体在肺间质性疾病患者中更为常见。单因素和多因素分析发现原发性特发性皮肌炎亚型、发病时咳嗽和呼吸困难是间质性肺疾病的三个独立临床预测因素。高血清乳酸脱氢酶水平（> 400 U/I）与间质性肺疾病的发生呈负相关（OR 0.088, p=0.031）。血清乳酸脱氢酶水平和抗jo1抗体的存在可作为肺部并发症的实验室指标。恶性肿瘤和发病年龄较大（60岁以上）的皮肌炎/多肌炎患者预后较差（p = 0.047和p=0.035）。间质性肺疾病不影响皮肌炎/多发性肌炎患者的生存。
The aim of this study was to define the predicting factors and evaluate the prognosis of interstitial lung disease in dermatomyositis/polymyositis. For the period 1995-2005, we retrospectively reviewed the clinical information and laboratory data of 56 patients who were diagnosed as definite and probable dermatomyositis and polymyositis. Interstitial lung disease is common (41.9%) in these patients. Dyspnoea and cough were the two most common initial presentations. Anti-Jol antibody was more common in those with interstitial lung disease. Univariate and multivariate analyses identified primary idiopathic dermatomyositis subtype, cough and dyspnoea at onset to be the three independent clinical predicting factors of interstitial lung disease. High serum lactate dehydrogenase level (> 400 U/I) was inversely associated with development of interstitial lung disease (OR 0.088, p=0.031). Serum lactate dehydrogenase level and presence of antiJo1 antibody can serve as laboratory indicators of lung complications. Patients with malignancy and older age at onset (more than 60 years) had poorer prognosis for dermatomyositis/polymyositis (p-0.047 and p=0.035, respectively). Interstitial lung disease did not affect the survival of dermatomyositis/polymyositis patients.