Prognostic factors in men with metastatic castration-resistant prostate cancer treated with cabazitaxel.
Prognostic factors in men with metastatic castration-resistant prostate cancer treated with cabazitaxel.
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DOI：
10.18632/oncotarget.22474
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发表时间：
2017-12-05
期刊：
影响因子：
--
通讯作者：
van Soest RJ
中科院分区：
文献类型：
--
作者：
Belderbos BPS;de Wit R;Hoop EO;Nieuweboer A;Hamberg P;van Alphen RJ;Bergman A;van der Meer N;Bins S;Mathijssen RHJ;van Soest RJ
随着疾病早期新疗法的引入，转移性去势耐受前列腺癌(MCRPC)的治疗选择已变得越来越具有挑战性。本研究的目的是确定卡巴紫杉醇治疗的mCRPC患者的总生存期(OS)和PSA应答的预后因素。224例mCRPC患者纳入本次分析。在多变量分析中，WHO工作状态、基线血红蛋白、碱性磷酸酶和白蛋白均与OS显著相关。血红蛋白和碱性磷酸酶与PSA应答显著相关。这项研究确定了卡巴紫杉醇治疗男性mCRPC患者的OS和PSA反应的预后因素。在一个日益复杂的治疗环境中，有几种治疗方案可供选择，我们的发现可能有助于估计有资格在日常实践中接受二线化疗治疗的男性的生存机会。此外，这些数据可用于在临床试验中对患者进行风险分层。我们对接受卡巴紫杉醇治疗的mCRPC患者进行了一项随机II期试验的后处理分析。用COX和Logistic回归模型分析临床和生化变量对OS和PSA反应的影响。绘制诺模图以评估PSA反应和OS的机会。
Treatment selection for men with metastatic castration-resistant prostate cancer (mCRPC) has become increasingly challenging with the introduction of novel therapies at earlier disease stages. The purpose of this study was to identify prognostic factors for overall survival (OS) and PSA response in patients with mCRPC treated with cabazitaxel. 224 mCRPC patients were included in the current analysis. In multivariable analysis, WHO performance status, baseline hemoglobin, alkaline phosphatase and albumin were all significantly associated with OS. Hemoglobin and alkaline phosphatase were significantly associated with PSA response. This study identified prognostic factors for OS and PSA response of men with mCRPC treated with cabazitaxel. In an increasingly complicated treatment landscape with several treatment options available our findings might serve to estimate the chance of survival of men qualifying for treatment with second-line chemotherapy in daily practice. Furthermore, these data can be used to risk-stratify patients in clinical trials. We performed a post-hoc analysis of a randomized phase II trial of mCRPC patients treated with cabazitaxel. Cox and logistic regression models were used to investigate the influence of clinical and biochemical variables on OS and PSA response. Nomograms were developed to estimate the chance of PSA response and OS.
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