Thermal dehydration-induced thirst in rats: role of angiotensin II.
Thermal dehydration-induced thirst in rats: role of angiotensin II.
复制标题
热脱水引起的大鼠口渴：血管紧张素 II 的作用。
DOI：
10.1152/ajpregu.1991.261.5.r1171
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kuiper,DH
中科院分区：
文献类型：
--
作者：
Barney,CC;Williams,JS;Kuiper,DH
脱水可以通过缺水或热暴露（热脱水）引起。血管紧张素II已被证明在缺水引起的口渴中起作用。目前的研究旨在确定血管紧张素II是否与热脱水引起的口渴有关。雄性Sprague-Dawley品系大鼠通过暴露于40 ℃环境2-4小时或通过缺水44小时而脱水。水剥夺，但不热暴露显着增加血浆肾素活性。热脱水后，输尿管结扎或肾切除均未显著改变饮水量。Captopril是一种血管紧张素转换酶抑制剂，以100 mg/kg的剂量ip给药，可显著降低缺水大鼠的饮水量，但对热脱水大鼠无影响。因此，血管紧张素II似乎并没有发挥作用，在热脱水大鼠的水摄入量的控制。大鼠对脱水的生理反应取决于脱水的方式。
Dehydration can be brought about by either water deprivation or by heat exposure (thermal dehydration). Angiotensin II has been shown to have a role in water deprivation-induced thirst. The current study was designed to determine whether angiotensin II is involved in thirst caused by thermal dehydration. Male Sprague-Dawley strain rats were dehydrated by exposure to a 40 degree C environment for 2-4 h or by water deprivation for 44 h. Water deprivation but not heat exposure significantly increased plasma renin activity. Neither ureteric ligation nor nephrectomy significantly altered water intake after thermal dehydration. Captopril, an inhibitor of angiotensin converting enzyme, given at a dose of 100 mg/kg ip, significantly decreased water intake in water-deprived rats but not in thermally dehydrated rats. Angiotensin II therefore does not appear to play a role in the control of water intake of thermally dehydrated rats. The physiological responses to dehydration in rats are dependent on the way in which the dehydration is brought about.