Modeling and Reproducibility of Twin Concentric Electrical Impedance Myography.
Modeling and Reproducibility of Twin Concentric Electrical Impedance Myography.
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DOI：
10.1109/tbme.2021.3063724
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Sanchez B
中科院分区：
文献类型：
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作者：
Cardoner MMM;Kwon H;Pulido HVG;Nagy J;Rutkove S;Sanchez B
电阻抗肌图(EIM)是一种评估肌肉健康的最新技术。到目前为止，EIM的临床应用仅应用于使用与皮肤接触的非侵入性表面电极来评估肌肉状况；然而，记录部位的中间组织引入了混杂伪影，降低了该技术作为神经肌肉疾病(NMD)生物标志物的性能。在这里，我们开发并在人类身上测试了一种使用两个同心针进行肌肉内EIM记录的新方法。首先，我们通过解析模型和有限元模型(FEMS)研究了双同心针EIM的记录特性。接下来，通过对生理盐水模型和琼脂模型的实验验证了模型的有效性。最后，对8例不同神经肌肉疾病的受试者进行了胫前肌、二头肌、三角肌、拇短内收肌、第一骨间背侧肌和腕屈肌的测量。解析模拟和有限元模拟的最大实验误差分别为<；8%和<；9%，分别与26号和30号测针的模拟结果一致。以所有被研究肌肉的组内相关系数衡量的会话间重复性为0.926，这与用于评估肌肉健康的其他成熟的电生理学测试的重复性相当或超过。该技术的重复性支持了未来针刺EIM用于评估疾病状态的临床验证，无论是作为标准患者护理的一部分，还是作为临床试验中的生物标记物测量。针头EIM有可能成为评估成人NMD的有价值的诊断工具。
Electrical impedance myography (EIM) is a recent technology to assess muscle health. As of today, the clinical application of EIM has been applied only to evaluate muscle condition using non-invasive surface electrodes in contact with the skin; however, intermediate tissues at the recording site introduce confounding artifacts which reduce the technique’s performance as a biomarker of neuromuscular disorders (NMD). Here, we develop and test in humans a new approach using two concentric needles for intramuscular EIM recordings. First, we study the recording characteristics of dual concentric needle EIM via analytical models and finite element models (FEMs). Next, the validity of the models is verified by performing experiments on saline and agar phantoms. Finally, 8 subjects with various neuromuscular diseases were studied measuring tibialis anterior, biceps, deltoid, adductor pollicis brevis, first dorsal interosseous and flexor carpi radialis muscles. Analytical and FEM simulations are in good agreement with a maximum experimental discrepancy <8% and <9% using gauge needles 26 and 30, respectively. The inter-session reproducibility, as measured by the intraclass correlation coefficients for all muscles studied, was 0.926, which is comparable or exceeds the reproducibility of other well-established electrophysiological tests to assess muscle health. The reproducibility of the technique support future clinical validation of needle EIM for assessment of disease status, either as part of standard patient care or as biomarker measure in clinical trials. Needle EIM has the potential of becoming a valuable diagnostic tool to evaluate NMD in adult population.