Polymersomes: Tough vesicles made from diblock copolymers
Polymersomes: Tough vesicles made from diblock copolymers
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DOI：
10.1126/science.284.5417.1143
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发表时间：
1999-05-14
期刊：
影响因子：
56.9
通讯作者：
Hammer, DA
中科院分区：
文献类型：
--
作者：
Discher, BM;Won, YY;Hammer, DA
囊泡由两亲性二嵌段共聚物制成，其特征在于通过显微操作。所研究的特定聚合物聚环氧乙烷-聚乙烯（EO 40-EE 37）的平均分子量是天然膜中典型磷脂的几倍。电铸聚合物囊泡（基于聚合物的脂质体）的膜弯曲模量和面积膨胀模量均落在脂质膜测量范围内，但巨型聚合物囊泡被证明几乎是一个数量级的韧性，并在破裂前持续更大的面积应变。聚合物囊泡膜对水的渗透性也比普通磷脂双层低至少10倍。结果表明，一类新的合成薄壳胶囊的基础上嵌段共聚物化学。
Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based Liposomes) fell within the range of Lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at Least 10 times Less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.