Quantification of vessel wall motion and cyclic strain using cine phase contrast MRI: In vivo validation in the porcine aorta
Quantification of vessel wall motion and cyclic strain using cine phase contrast MRI: In vivo validation in the porcine aorta
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DOI：
10.1002/mrm.20137
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Taylor, CA
中科院分区：
文献类型：
--
作者：
Draney, MT;Arko, FR;Taylor, CA
血管壁的运动和应变在血管重构中起重要作用，可能是血管疾病的发病机制之一。在人体主动脉中的周向不均匀壁运动的体内观察表明，不均匀的应变可能有助于血管病变的本地化。一个基于速度的方法来研究周向应变的变化，以前开发和验证在体外，目前的研究进行，以确定是否可以从体内获得的速度数据计算出准确的位移和应变场。用PC-MRI和植入的线圈量化猪胸主动脉的壁速度，然后进行时间积分以计算壁位移轨迹和循环应变。位移轨迹与观察到的主动脉壁运动以及主动脉壁中标记的位移一致。基于速度和基于标记的轨迹点之间的平均差异为0.1 mm，相对于0.4 mm的平均像素大小。基于计算位移精度的误差分析的传播用于证明10%应变导致3.6%的标准差。这项研究表明，它是可行的，以准确地量化应变从低壁速度在体内，猪胸主动脉不变形均匀。(C)2004 Wiley-Liss，Inc.
Artery wall motion and strain play important roles in vascular remodeling and may be important in the pathogenesis of vascular disease. In vivo observations of circumferentially nonuniform wall motion in the human aorta suggest that nonuniform strain may contribute to the localization of vascular pathology. A velocity-based method to investigate circumferential strain variations was previously developed and validated in vitro; the current study was undertaken to determine whether accurate displacement and strain fields can be calculated from velocity data acquired in vivo. Wall velocities in the porcine thoracic aorta were quantified with PC-MRI and an implanted coil and were then time-integrated to compute wall displacement trajectories and cyclic strain. Displacement trajectories were consistent with observed aortic wall motion and with the displacements of markers in the aortic wall. The mean difference between velocity-based and marker-based trajectory points was 0.1 mm, relative to an average pixel size of 0.4 mm. Propagation of error analyses based on the precision of the computed displacements were used to demonstrate that 10% strain results in a standard deviation of 3.6%. This study demonstrates that it is feasible to accurately quantify strain from low wall velocities in vivo and that the porcine thoracic aorta does not deform uniformly. (C) 2004 Wiley-Liss, Inc.