Poly(caprolactone) based magnetic scaffolds for bone tissue engineering
Poly(caprolactone) based magnetic scaffolds for bone tissue engineering
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DOI：
10.1063/1.3561149
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发表时间：
2011-04-01
影响因子：
3.2
通讯作者：
Rivas, J.
中科院分区：
文献类型：
--
作者：
Banobre-Lopez, M.;Pineiro-Redondo, Y.;Rivas, J.
与干细胞偶联的用于组织工程的合成支架代表了旨在促进受损组织或器官的大缺损的再生的有前途的方法。磁性纳米复合材料形成的生物可降解的聚（己内酯）（PCL）矩阵和超顺磁性铁掺杂的羟基磷灰石（FeHA）纳米粒子在不同的PCL/FeHA组合物已成功地原型化，层对层，通过3D生物绘图。进行磁性测量、机械测试和成像以校准磁化支架原型中的模型和技术处理。10%w/w的量的磁性FeHA纳米颗粒代表PCL基质的增强，然而，也观察到失效时的应变的减少。在所得到的磁性支架中进行了射频施加磁场下的能量损失（吸收）测量，并观察到非常有前途的加热性能，使其对于潜在的生物医学应用非常有用。(C)2011年美国物理学会。[doi：10.1063/1.3561149]
Synthetic scaffolds for tissue engineering coupled to stem cells represent a promising approach aiming to promote the regeneration of large defects of damaged tissues or organs. Magnetic nanocomposites formed by a biodegradable poly(caprolactone) (PCL) matrix and superparamagnetic iron doped hydroxyapatite (FeHA) nanoparticles at different PCL/FeHA compositions have been successfully prototyped, layer on layer, through 3D bioplotting. Magnetic measurements, mechanical testing, and imaging were carried out to calibrate both model and technological processing in the magnetized scaffold prototyping. An amount of 10% w/w of magnetic FeHA nanoparticles represents a reinforcement for PCL matrix, however, a reduction of strain at failure is also observed. Energy loss (absorption) measurements under a radio-frequency applied magnetic field were performed in the resulting magnetic scaffolds and very promising heating properties were observed, making them very useful for potential biomedical applications. (C) 2011 American Institute of Physics. [doi:10.1063/1.3561149]