An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination
An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination
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DOI：
10.1016/j.mito.2013.04.011
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发表时间：
2013-07-01
期刊：
影响因子：
4.4
通讯作者：
Yao, Yong-Gang
中科院分区：
文献类型：
--
作者：
Fan, Long;Yao, Yong-Gang
人类线粒体DNA(MtDNA)单倍群的确定不仅在人类学和法医学研究中至关重要，而且在医学领域也有助于防止错误的疾病关联的建立。近年来，高通量技术及其产生的海量数据，以及对mtDNA系统发育树的定期更新，意味着需要一种自动化方法，能够比使用传统的人工方法更快地确定单倍群。在这里，我们更新了MitoTool(www.mitotool.org)，将一种新的用于确定mtDNA的评分系统整合到单倍群中，该系统在速度、准确性和易于实施方面具有优势。为了便于访问MitoTool，我们还提供了可在本地计算机上运行的程序的独立版本，该版本可在MitoTool网站上免费获得。(C)2013年爱思唯尔公司和线粒体研究会。版权所有。
The determination of human mitochondrial DNA (mtDNA) haplogroups is not only crucial in anthropological and forensic studies, but is also helpful in the medical field to prevent establishment of wrong disease associations. In recent years, high-throughput technologies and the huge amounts of data they create, as well as the regular updates to the mtDNA phylogenetic tree, mean that there is a need for an automated approach which can make a speedier determination of haplogroups than can be made by using the traditional manual method. Here, we update the MitoTool (www.mitotool.org) by incorporating a novel scoring system for the determination of mtDNA into haplogroups, which has advantages on speed, accuracy and ease of implementation. In order to make the access to MitoTool easier, we also provide a stand-alone version of the program that will run on a local computer and this version is freely available at the MitoTool website. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.