Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons.
Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons.
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HIV 血清阳性者暴露的血清阴性伴侣血清中的人类免疫缺陷病毒 (HIV) 特异性 IgA 和 HIV 中和活性。
DOI：
10.1086/314934
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
M. Clerici
中科院分区：
文献类型：
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作者：
S. Mazzoli;L. Lopalco;A. Salvi;D. Trabattoni;S. Lo Caputo;F. Semplici;M. Biasin;C. Bl;Antonio Cosma;C. Pastori;F. Meacci;F. Mazzotta;M. Villa;A. Siccardi;M. Clerici
对 15 名具有全身 HIV 特异性细胞介导免疫和 IgA 介导粘膜免疫的性暴露血清阴性者及其 HIV 感染伴侣的血清中人类免疫缺陷病毒 (HIV) 特异性抗体的存在和活性进行了分析。 HIV阳性受试者血清中存在HIV特异性IgG和IgA；血清阴性者在缺乏 IgG 的情况下具有 HIV 特异性血清 IgA。中断高危性行为一年后对血清阴性者进行的检测显示，没有发生 IgG 血清转化，并且 HIV 特异性 IgA 血清浓度有所下降。分析了暴露于 HIV 的血清阴性者的血清中和初级 HIV-1 分离株的能力。 15 份血清中有 5 份检测到中和活性，其中 2 份血清纯化的 IgA 保留了中和活性。因此，抵抗 HIV 感染的免疫学图景应包括 HIV 特异性细胞介导的免疫以及 HIV 特异性 IgA 介导的粘膜和全身免疫。
The presence and activity of human immunodeficiency virus (HIV)-specific antibodies were analyzed in the sera of 15 sexually exposed seronegative persons who had systemic HIV-specific cell-mediated immunity and IgA-mediated mucosal immunity and in their HIV-infected partners. The HIV-positive subjects had HIV-specific serum IgG and IgA; the seronegative persons had HIV-specific serum IgA in the absence of IgG. Testing of the seronegative persons 1 year after the interruption of at-risk sex showed that no IgG seroconversion had occurred and that HIV-specific IgA serum concentrations had declined. Serum from the HIV-exposed seronegative persons was analyzed for the ability to neutralize primary HIV-1 isolates. Neutralizing activity was detected in 5 of 15 sera and in 2 cases was retained by serum-purified IgA. Thus, the immunologic picture for resistance to HIV infection should include HIV-specific cell-mediated immunity as well as HIV-specific IgA-mediated mucosal and systemic immunity.
一种静息细胞测定，用于改进抗体介导的 HIV 1 型初级分离株中和的检测。
DOI：
10.1089/aid.1995.11.1449
发表时间：
1995
期刊：
AIDS research and human retroviruses.
影响因子：
--
作者：
Zolla-Pazner,S;Sharpe,S
通讯作者：
Sharpe,S