Graft vs. Host Disease, Third Edition
Graft vs. Host Disease, Third Edition
复制标题
移植物抗宿主病，第三版
DOI：
10.1201/b14165
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
H. Deeg
中科院分区：
文献类型：
--
作者：
J. Ferrara;K. Cooke;H. Deeg
移植免疫生物学：胸腺T细胞发育MHC 1类：结构和功能MHC II类：结构和功能淋巴细胞辅助受体抗原特异性免疫抑制免疫抑制和免疫亲和素配体：环孢菌素A，FK 506和雷帕霉素白细胞粘附，运输和迁移细胞因子网络T细胞介导的细胞毒性机制在体内和体外自然杀伤细胞。GVHD病理生理学-靶器官：免疫系统：GVHD的效应器和靶点皮肤移植物抗宿主病的细胞病理学肝肠道宿主病移植物抗疾病移植物抗白血病与移植物抗疾病相关的肺损伤宿主反应：GVHD对造血系统的影响。网络激活和失调：移植物与作为Th-1型过程的宿主疾病：供体细胞对Th 2细胞因子表型的调节：内毒素在急性移植物抗宿主病发病机制中的作用宿主疾病。临床GVHD -预防和治疗：移植物与宿主疾病同基因/自体移植物与输血相关宿主病宿主疾病。目前的策略：组织相容性抗原在移植物抗宿主病发展中的作用宿主疾病T细胞耗竭对人类GVHD的预防体内GVHD的预防和治疗炎性细胞因子拮抗剂：预防和治疗应用白细胞介素-10在移植和GVHD中的作用替代办法：造血干细胞移植中的阳性干细胞选择，骨髓移植中的过继免疫治疗，基因治疗的最新进展和未来方向。
Transplantation immunobiology: thymic T-cell development MHC class 1: structure and function MHC class II: structure and function biological inhibitors of lymphocyte coreceptors for antigen-specific immunosuppression immunosuppression andimmunophilin ligands: cyclosporin A, FK506, and rapamycin leucocyte adhesion, trafficking, and migration cytokine networks mechanisms of T-cell-mediated cytotoxicity in vivo and in vitro natural killer cells. GVHD pathophysiology - target organs: theimmune system: effector and target of Graft-vs.-Host disease cellular pathology of cutaneous Graft-vs-Host disease Graft-vs.-Host disease of the liver intestinal Graft-vs. disease Graft versus leukaemia lung injuries associated with Graftvs.-Hostreactions the effect of GVHD on the haematopoietic system. Network activation and dysregulation: Graft-vs.-Host disease as the Th-1 type process: regulation by donor cells of Th2 cytokine phenotype the role of endotoxin in the pathogenesis of acuteGraft-vs.-Host disease. Clinical GVHD - prevention and treatment: clinical spectrum of Graft-vs.-Host disease the immunobiology of syngeneic/autologous Graft-vs.-Host disease transfusion-associated Graft-vs.-Host disease. Current strategies: role ofhistocompatibility antigens in the development of graft-vs.-Host disease T-cell depletion of GVHD prevention in humans in vivo prevention and treatment of GVHD antagonists of inflammatory cytokines: prophylactic and therapeutic applications the roleof interleukin-10 in transplantation and GVHD. Alternative approaches: positive stem-cell selection for hermatopoietic transplantation adoptive immunotherapy in bone marrow transplantation genetherapy recent advances and future directions.