Rates of behavior and aging specified by mitochondrial function during development
Rates of behavior and aging specified by mitochondrial function during development
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DOI：
10.1126/science.1077780
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发表时间：
2002-12-20
期刊：
影响因子：
56.9
通讯作者：
Kenyon, C
中科院分区：
文献类型：
--
作者：
Dillin, A;Hsu, AL;Kenyon, C
为了探究线粒体活动在衰老过程中的作用，我们利用RNA干扰（RNAi）技术降低了秀丽隐杆线虫电子传递链和腺苷5'-三磷酸（ATP）合酶的活性。这些干扰降低了体型和行为速率，并延长了成虫的寿命。在成虫期将信使RNA恢复到接近正常水平并没有提高ATP水平，也没有纠正任何这些表型。相反，仅在成虫期抑制呼吸链成分并没有重置行为速率，也没有影响寿命。因此，发育中的动物似乎包含一个调节系统，该系统在生命早期监测线粒体活动，并相应地建立在成年期持续存在的呼吸、行为和衰老速率。
To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.