Young adults with coeliac disease may be at increased risk of early atherosclerosis
Young adults with coeliac disease may be at increased risk of early atherosclerosis
复制标题
DOI：
10.1111/apt.12360
复制
发表时间：
2013-07-01
影响因子：
7.6
通讯作者：
Arosio, E.
中科院分区：
文献类型：
--
作者：
De Marchi, S.;Chiarioni, G.;Arosio, E.
背景免疫介导性疾病中动脉粥样硬化进展加速和心血管风险增加已被描述，但在乳糜泻中几乎没有数据可用。目的评价20名成人在首次诊断为乳糜泻时和无麸质饮食后6-8个月的动脉粥样硬化风险的仪器和生化指标。方法分析总胆固醇、高密度脂蛋白、低密度脂蛋白、胆固醇、甘油三酯、同型半胱氨酸、C反应蛋白、叶酸和维生素B12，并在诊断时和停面筋后进行颈动脉内膜中层厚度(IMT)和内皮依赖性扩张的超声测量。22名健康的医院工作人员作为血管检查的匹配对照。结果基线时，平均总胆固醇和高密度脂蛋白-胆固醇均在正常范围内，而平均低密度脂蛋白-胆固醇浓度略有升高；饮食与总胆固醇和高密度脂蛋白的升高有关(68.2+/-17.4比51.4+/-18.6 mg/dL；P
Background Accelerated progression of atherosclerosis and increased cardiovascular risk have been described in immune-mediated disorders, but few data are available in coeliac disease. Aim To evaluate instrumental and biochemical signs of atherosclerosis risk in 20 adults at first diagnosis of coeliac disease and after 6-8months of gluten-free diet with mucosal recovery. Methods We analysed total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, homocysteine, C-reactive protein, folate and vitamin B12; ultrasound measurement of carotid intima-media thickness (IMT) and endothelium-dependent dilatation were both carried on at diagnosis and after gluten withdrawal. Twenty-two healthy members of the hospital staff served as matched controls for vascular examinations. Results At baseline, mean total and HDL-cholesterol (HDL-C) were both within normal range, while mean LDL-cholesterol concentration was slightly increased; diet was associated with an increment in total and HDL-C (68.2 +/- 17.4 vs. 51.4 +/- 18.6mg/dL; P