Manipulation of Magnetically Labeled and Unlabeled Cells with Mobile Magnetic Traps
Manipulation of Magnetically Labeled and Unlabeled Cells with Mobile Magnetic Traps
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DOI：
10.1016/j.bpj.2009.10.036
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发表时间：
2010-02-03
影响因子：
3.4
通讯作者：
Sooryakumar, R.
中科院分区：
文献类型：
--
作者：
Henighan, T.;Chen, A.;Sooryakumar, R.
在表面上图案化的离散微观磁性元件的平台通过对磁位内的磁化进行重新编程来提供对流体携带细胞的运动的动态控制。拴在磁性微球上的T淋巴细胞和未捆绑的白血病细胞通过指向力在硅表面上沿着所需的轨迹进行远程操纵和引导，平均速度高达20微米/S。除了导航细胞外，微球还可以在远处操作，推动生物和惰性实体，并在流体环境中充当局部探针。
A platform of discrete microscopic magnetic elements patterned on a surface offers dynamic control over the motion of fluid-borne cells by reprogramming the magnetization within the magnetic bits. T-lymphocyte cells tethered to magnetic microspheres and untethered leukemia cells are remotely manipulated and guided along desired trajectories on a silicon surface by directed forces with average speeds up to 20 mu m/s. In addition to navigating cells, the microspheres can be operated from a distance to push biological and inert entities and act as local probes in fluidic environments.