Mutans streptococci in preschool twins
Mutans streptococci in preschool twins
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DOI：
10.1016/j.archoralbio.2004.08.010
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发表时间：
2005-03-01
影响因子：
3
通讯作者：
Vanyukov, M
中科院分区：
文献类型：
--
作者：
Corby, PMA;Bretz, WA;Vanyukov, M
目的：探讨遗传因素是否影响学龄前双生子唾液中变形链球菌(MS)水平的变化。设计：研究人群包括48对同卵双胞胎(MZ)和54对异卵双胞胎(DZ)。对8个高度多态的DNA标记进行基因分型，确定了合子。母亲报告的人口统计数据和抗生素暴露情况是通过面对面采访获得的。唾液中的MS水平通过Strimuans(TM)试验进行测定。测试结果在0-3分的范围内报告。采用回归分析、两样本t检验和结构方程模型对数据进行分析。结果：只有6%的人去看过牙医(该人群的DMFS的F分量为0)。变形链球菌的平均唾液得分在MZ(1.1+/-0.1)和DZ(0.8+/-0.1)双胞胎之间有显著差异(p=0.021)。42%的MZ双胞胎和26%的DZ双胞胎的唾液中有高水平的MS(2分和3分)。对MS唾液水平的回归分析显示，年龄、性别和抗生素摄入对MZ或DZ双胞胎没有显著影响。变形链球菌在48对MZ和26对DZ双胞胎中定植的遗传率估计为52%。非共享环境的贡献率估计为48%。结论：这些结果表明变形链球菌唾液水平的差异是由遗传因素造成的。(C)2004爱思唯尔有限公司。保留所有权利。
Objective: The purpose of this study was to determine whether genetic factors influence variation in salivary levels of the mutans streptococci (MS) in preschool twins.Design: The study population consisted of 48 pairs of monozygotic (MZ) twins and 54 pairs of dizygotic (DZ) twins. Genotyping eight highly polymorphic DNA markers determined zygosity. Demographic data and antibiotic exposure as reported by mothers were obtained by a face-to-face interview. Salivary levels of MS were determined by the Stripmutans (TM) test. Test results are reported on a scale of 0-3. Regression analysis, two sample t-tests and structural equation modeling were applied to analyse the data.Results: Only 6 % of the participants ever visited a dentist (F component of the DMFS was 0 for this population). Average salivary scores for the mutans streptococci were significantly different between MZ (1.1 +/- 0.1) and DZ (0.8 +/- 0.1) twins (p = 0.021). High salivary levels of MS (scores 2 and 3) were observed in 42 % of MZ twins and in 26 % of DZ twins. Regression analysis on the MS salivary levels revealed no significant effects of age, gender and antibiotic intake for MZ or DZ twins. The heritability of mutans streptococci colonisation in 48 pairs MZ and in 26 pairs of DZ twins was estimated to be 52 %. The non-shared environment contribution was estimated to be 48 %.Conclusions: These results suggest that variation in the salivary levels of the mutans streptococci is significantly contributed by genetic factors. (c) 2004 Elsevier Ltd. All rights reserved.