Growth hormone treatment in a child with Williams-Beuren syndrome: a case report
Growth hormone treatment in a child with Williams-Beuren syndrome: a case report
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DOI：
10.1007/s004310051118
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发表时间：
1999-06-01
影响因子：
3.6
通讯作者：
Jansen, M
中科院分区：
文献类型：
--
作者：
Kuijpers, GMC;De Vroede, M;Jansen, M
生长迟缓是Williams-Beuren综合征的一致发现。这种综合征中身材矮小的原因尚不清楚。内分泌研究未能揭示生长激素-胰岛素样生长因子I轴的异常。我们报告一个男孩证实Williams-Beuren综合征，谁被发现有经典的生长激素缺乏症和生长激素therapy.Conclusion反应良好，虽然生长激素缺乏症不太可能是一个常见的原因，身材矮小的Williams-Beuren综合征，我们仍然建议在所有情况下的生长激素-胰岛素样生长因子I轴的评价。
Growth retardation is a consistent finding in Williams-Beuren syndrome. The cause of short stature in this syndrome is unknown. Endocrine studies have failed to reveal abnormalities in the growth hormone - insulin-like growth factor I axis. We report a boy with confirmed Williams-Beuren syndrome, who was found to have classical growth hormone deficiency and responded well to growth hormone therapy.Conclusion Although growth hormone deficiency is not likely to be a common cause of Short stature in Williams-Beuren syndrome, we nevertheless recommend evaluation of the growth hormone - insulin-like growth factor I axis in all cases.