Effects of Ionizing Radiation
Effects of Ionizing Radiation
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DOI：
10.1007/978-1-4615-7175-9_22
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
E. Egaña
中科院分区：
文献类型：
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作者：
E. Egaña
电离辐射对生长期和成年期中枢神经系统影响的研究，似乎是与本手册的总主题直接相关的一个方面，因为它涉及到神经轴的“放射性生物化学损伤”。这种影响可能类似于其他有毒制剂产生的影响。因为我们在这里讨论的是电离辐射影响神经组织的内在机制，所以在本章的开头有一个放射生物学的综述。神经放射生物化学是神经化学中最不为人所知的前沿领域之一，在专业期刊、会议或研讨会上发表的论文中，神经放射生物化学不超过1%至2%，尽管CNS在结构上是动物经济的最佳系统，在生物学上是最容易记录外部介质的任何能量变化的系统;可以设想，辐射能的吸收将迅速转化为系统的物理化学、生物化学和功能改变。在这一章中，我们将提到具有重大意义的神经放射化学事实，并试图尽可能解释可能与这些过程有关的最终机制。在过去的8年中，许多书籍，评论和文章已经发表了电离辐射对中枢神经系统的影响。它们包含了对放射神经生化研究的极好的参考。（1-22）
The study of the effects of ionizing radiations on both growing and adult CNS appears as an aspect directly related to the general theme of this Handbook, since it refers to the “radiobiochemical lesion” of the neuroaxis. Such effects can resemble those produced by other noxious agents. Because we deal here with the intrinsic mechanism through which the ionizing radiation affects the nervous tissue, there is a radiobiological review at the beginning of the chapter. Neuroradiobiochemistry, one of the least known and cultivated frontiers of neurochemistry, does not represent more than 1 to 2% of the published papers of specialized journals, congresses, or symposia, in spite of the fact that the CNS is structurally the best system of animal economy and biologically the one most apt to register any energy change of the external medium; it could be supposed that the absorption of radiant energy would be rapidly transformed into physicochemical, biochemical, and functional alterations of the system. In this chapter we shall refer to neuroradiochemical facts of major significance, attempting to explain, as far as possible, the eventual mechanisms which may have bearing on such processes. In the past 8 years numerous books, reviews, and articles have been published on the effect of ionizing radiation on CNS. They contain excellent references to the radioneurobiochemical studies.(1–22)