Involvement of Cytochrome P450 in Conferring Chloroquine Resistance to the Malarial Parasite, Plasmodium falciparum
Involvement of Cytochrome P450 in Conferring Chloroquine Resistance to the Malarial Parasite, Plasmodium falciparum
复制标题
细胞色素 P450 参与赋予氯喹对疟疾寄生虫恶性疟原虫的抗性
DOI：
10.1006/bbrc.1993.2516
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
G. Padmanaban
中科院分区：
文献类型：
--
作者：
N. Surolia;G. Karthikeyan;G. Padmanaban
The higher levels of cytochrone P-450 dependent enzyme activities reported earlier are traced to higher levels of cytochrome P-450 (CYPIIB1/B2 like) messenger RNA in the chloroquine resistant than the sensitive strains. The messenger RNA is also induced by phenobarbitone in the sensitive strain. Pretreatment with phenobarbitone affords partial protection to chloroquine toxicity in the sensitive strain and this is not due to a differential accumulation of the drug.
