Isoprenylated Chromone Derivatives from the Plant Endophytic Fungus Pestalotiopsis fici
Isoprenylated Chromone Derivatives from the Plant Endophytic Fungus Pestalotiopsis fici
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来自植物内生真菌 Pestalotiopsis fici 的异戊二烯化色酮衍生物。
DOI：
10.1021/np900308s
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发表时间：
2009-08-01
影响因子：
5.1
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
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作者：
Liu, Ling;Liu, Shuchun;Che, Yongsheng
Pestaloficiols F-L（1-7）是从植物内生真菌拟盘多毛孢（Pestalotiopsis fici）的放大发酵提取物中分离得到的一种新的异戊烯化色酮衍生物，其中包括一个异二聚体（7）。通过NMR和MS方法初步鉴定了这些化合物的结构。使用改进的Mosher方法指定了1和4的绝对构型。化合物1-3、5和6显示对C8166细胞中HIV-1复制的抑制作用，而化合物4-7显示对人肿瘤细胞系HeLa和MCF 7的细胞毒活性。
Pestaloficiols F-L (1-7), new isoprenylated chromone derivatives including one heterodimer (7), have been isolated from a scale-up fermentation extract of the plant endophytic fungus Pestalotiopsis fici. The structures of these compounds were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 4 were assigned using the modified Mosher method. Compounds 1-3, 5, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 4-7 showed cytotoxic activity against the human tumor cell lines HeLa and MCF7.