A new halo aldol reaction: three-component reaction via 1,4-robust activation of ethynyl alkyl ketones for stereoselective formations of versatile aldol adducts.
A new halo aldol reaction: three-component reaction via 1,4-robust activation of ethynyl alkyl ketones for stereoselective formations of versatile aldol adducts.
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一种新的卤代羟醛反应：通过乙炔基烷基酮的 1,4-稳健活化实现多用途羟醛加合物的立体选择性形成的三组分反应。
DOI：
10.1021/ol020146y
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发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Li,Guigen
中科院分区：
文献类型：
--
作者：
Wei,Han-Xun;Kim,SunHee;Li,Guigen
发现了一个新的三组分卤代羟醛缩合反应，通过活化α，β-炔酮的β ′，β-位形成I-C/C-C键。关键中间体1-碘-3-硅氧基-1，3-丁二烯由丙二烯醇化物生成，并通过1HNMR光谱分析直接监测。在10个实施例中实现了优异的几何选择性（>95%）和良好的产率（65 - 82%）。
A new three-component halo aldol reaction has been discovered for the tandem formations of I−C/C−C bonds by activating the α‘,β-positions of α,β-acetylenic ketones. The key intermediates, 1-iodo-3-siloxy-1,3-butadienes, were generated from allenolates and directly monitored by1H NMR spectroscopic analysis. Excellent geometric selectivity (>95%) and good yields (65−82%) have been achieved for 10 examples.