Chronic food restriction enhances memory in mice - analysis with matched drive levels
Chronic food restriction enhances memory in mice - analysis with matched drive levels
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DOI：
10.1097/00001756-200507130-00019
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发表时间：
2005-07-13
期刊：
影响因子：
1.7
通讯作者：
Watanabe, S
中科院分区：
文献类型：
--
作者：
Hashimoto, T;Watanabe, S
采用干式水迷宫、主动回避和被动回避，比较了慢性和急性食物剥夺对C57BL/6L小鼠学习记忆的影响。在急性和慢性食物匮乏的情况下，动物的驱动力水平与累进比率时间表相匹配。这两种剥夺都导致了动物的高度活动；然而，急性饮食限制的动物并没有表现出比随意喂养的动物明显更好的表现，而长期食物剥夺的动物表现出记忆增强。这些影响是微妙的，在学习的后期才被发现。这些发现表明，慢性食物限制除了增加活动外，还会导致记忆巩固或对记忆减少的抵抗。
We compared the effects of chronic and acute food deprivation on learning and memory using a dry-type water maze, active avoidance and passive avoidance in C57BL/6L mice. The drive level of the animals - under acute and chronic food deprivation - was matched by a progressive ratio schedule. Both deprivations led to a high degree of activity in the animals; however, the animals on an acute dietary restriction did not exhibit a significantly better performance than those on ad libitum feeding, while those on a chronic food deprivation exhibited memory enhancement. These effects were subtle and were found at a later stage of learning. These findings suggest that chronic food restriction induces memory consolidation or resistance to memory reduction in addition to increased activity.