Quantitative CT in the measurement of bone quantity and bone quality for assessing osteoporosis
Quantitative CT in the measurement of bone quantity and bone quality for assessing osteoporosis
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DOI：
10.1016/1350-4533(96)00011-2
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发表时间：
1996-10-01
影响因子：
2.2
通讯作者：
Dougherty, G
中科院分区：
文献类型：
--
作者：
Dougherty, G
骨骼的生物力学强度以及未来骨折的风险取决于骨量（根据骨矿物质密度评估）和完成质量（根据其内部结构的完整性评估）。精确的方法来测量的骨小梁和皮质成分的椎体骨定量计算机断层扫描的钙当量密度。对于一组绝经后科威特女性，我们已经表明，在L3和L4腰椎水平，骨小梁和皮质成分彼此高度相关，相关系数分别为0.78和0.74（P < 0.0001）。我们已经探索了骨小梁的各向异性分布，并考虑使用标准差和骨小梁CT值的变异系数作为纹理指标和骨质量的替代指标。变异系数是更好的纹理指标：与骨矿物质密度值一起使用，它成功区分了两类患者（骨折和非骨折），具有高灵敏度（大于或等于89%）和特异性（大于或等于82%）。版权所有（C）1996爱思唯尔科学有限公司为IPEMB。
The biomechanical strength of the skeleton, and hence the risk of future fractures, depends on both the bone quantity (assessed in terms of bone mineral density) and Done quality (assessed in terms of the integrity of its internal architecture). Precise methods of measuring the calcium-equivalent density of both the trabecular and cortical components of vertebral bone using quantitative computed tomography are presented. For a group of Post-menopausal Kuwaiti females, we have shown that the trabecular and cortical components are highly correlated with each other at both the L3 and L4 lumbar vertebral levels, with correlation coefficients of 0.78 and 0.74 (P < 0.0001) respectively. We have explored the anisotropic distribution of trabecular bone and considered the use of the standard deviation and the coefficient of variation of trabecular CT numbers as texture Indicators and surrogate measures of bone quality. The coefficient of variation was the better texture indicator: used with bone mineral density values it successfully discriminated between two classes of patients (those with fractures and those without) with high sensitivity (greater than or equal to 89%) and specificity (greater than or equal to 82%). Copyright (C) 1996 Elsevier Science Ltd for IPEMB.