Chronotropic incompetence as a predictor of dDeath among patients with normal electrograms taking Beta blockers (metoprolol or atenolol)
Chronotropic incompetence as a predictor of dDeath among patients with normal electrograms taking Beta blockers (metoprolol or atenolol)
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DOI：
10.1016/j.amjcard.2005.06.082
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发表时间：
2005-11-01
影响因子：
2.8
通讯作者：
Lauer, MS
中科院分区：
文献类型：
--
作者：
Khan, MN;Pothier, CE;Lauer, MS
变时性功能不全或运动期间无法提高心率可以独立预测未服用β受体阻滞剂的患者的死亡。它是否可以预测服用β受体阻滞剂的患者的死亡尚不清楚。前瞻性研究队列由连续服用酒石酸美托洛尔或阿替洛尔的患者（n = 3,736；平均年龄 58 +/- 11 岁；68% 为男性）组成，这些患者从 1990 年到 2002 年被转介到一家主要学术医疗中心进行症状限制运动测试。没有人患有心力衰竭、起搏器、心房颤动或任何心电图异常。对患者的全因死亡率进行了平均 4.5 年的随访。变时性反应定义为使用的心率储备的百分比。值为
Chronotropic incompetence, or an inability to increase heart rate during exercise, independently predicts death in patients not taking beta blockers. Whether it predicts death in patients taking beta blockers is not known. Consecutive patients (n = 3,736; mean age 58 +/- 11 years; 68% men), who were taking either metoprolol tartrate or atenolol and were referred for symptom-limited exercise testing from 1990 to 2002 at a major academic medical center, formed the prospective study cohort. None had heart failure, pacemakers, atrial fibrillation, or any electrocardiographic abnormalities. Patients were followed for a median of 4.5 years for all-cause mortality. Chronotropic response was defined as the percentage of heart rate reserve used. A value of