Disrupted brain connectome in semantic variant of primary progressive aphasia
Disrupted brain connectome in semantic variant of primary progressive aphasia
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DOI：
10.1016/j.neurobiolaging.2014.05.017
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发表时间：
2014-11-01
影响因子：
4.2
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Agosta, Federica;Galantucci, Sebastiano;Filippi, Massimo
采用静息态功能磁共振成像和图形分析，探讨了原发性进行性失语症左侧起病语义变异（SV）患者与健康对照者的功能性脑网络连接的拓扑组织。与对照组相比，SV患者的功能性脑网络的特征是平均网络度、聚类系数和全局效率显著降低，特征路径长度较长，重复性较高。SV患者也表现出强烈的左侧损失枢纽，并减少节点的程度在下和腹侧颞区和枕叶皮质。在SV中，降低的节点程度延伸到双侧内侧和腹侧额叶皮质、左侧杏仁核和/或海马以及左侧尾状核。这些研究结果提供的证据表明，局灶性结构退化的下颞叶，和perysilvian语言区域的SV患者最终导致分布模式的功能连接异常。局部网络分析表明，SV与“泛模态”下颞区和/或腹侧颞区的功能退化以及腹侧加工通路的“模态特异性”视皮层起源有关。(C)2014爱思唯尔公司All rights reserved.
Using resting-state functional magnetic resonance imaging and graph analysis, the topological organization of the functional brain network connectivity was explored in patients with left-sided onset semantic variant (SV) of primary progressive aphasia relative to healthy controls. Functional brain networks in SV patients were characterized by a significantly lower mean network degree, clustering coefficient, and global efficiency, longer characteristic path length and higher assortativity compared with controls. SV patients showed also a strongly left-lateralized loss of hubs, and reduced nodal degree in the inferior and ventral temporal regions and occipital cortices. In SV, the decreased nodal degree extended into the medial and ventral frontal cortex bilaterally, left amygdala and/or hippocampus, and left caudate nucleus. These findings provide evidence that the focal structural degeneration of the inferior temporal, and perysilvian language regions in SV patients ultimately results in a distributed pattern of functional connectivity abnormalities. The local network analysis shows that SV is associated witha functional degradation in the "pan-modal" inferior and/or ventral temporal regions, and the "modality-specific" visual cortical origin of the ventral processing pathway. (C) 2014 Elsevier Inc. All rights reserved.