Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
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DOI：
10.1080/00016340601151949
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发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Wald, Anna
中科院分区：
文献类型：
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作者：
Brown, Elizabeth L.;Gardella, Carolyn;Wald, Anna
背景资料。新生儿单纯疱疹病毒(HSV)是一种罕见但毁灭性的疾病。我们对3个队列的数据进行了综合分析，以评估母亲HSV血清状态和HSV类型对新生儿感染HSV的风险和严重程度的影响。方法：研究方法。使用Mantel-Haenszel方法合并来自华盛顿州西雅图、美国加州斯坦福和瑞典斯德哥尔摩的队列数据。结果。有记录的新生儿HSV和已知的母体HSV血清状态的78名婴儿包括在内。HSV血清阴性妇女所生婴儿与HSV-1血清阳性妇女所生婴儿感染HSV-2的风险相似(合并OR：1.6；95%CI：0.6-4.0)。接触母体HSV-1的新生儿感染HSV的几率高于接触HSV-2的新生儿(调整后合并OR：19.2-3.95%CI：5.8-63.6)。新获得性生殖器疱疹患者所生婴儿传播HSV的几率在斯德哥尔摩被观察到(OR=13.5；95%CI：1.4-630)，但在西雅图或斯坦福没有观察到。结论。我们的结果表明，母体HSV-1抗体对新生儿HSV-2感染几乎没有保护作用(如果有的话)。在重新激活期间，HSV-1似乎比HSV-2更容易传播给新生儿，这是一个令人担忧的发现，因为生殖器HSV-1感染的频率不断上升。
Background. Neonatal herpes simplex virus (HSV) is a rare but devastating disease. We have conducted pooled analyses of data from 3 cohorts to evaluate the effects of maternal HSV serostatus and HSV type on risk of neonatal HSV acquisition and severity. Methods. Data from cohorts in Seattle, WA, and Stanford, CA, USA, and Stockholm, Sweden were pooled using Mantel-Haenszel methods. Results. Seventy-eight infants with documented neonatal HSV and known maternal HSV serostatus were included. The risk of neonatal HSV-2 infection was similar in infants born to HSV seronegative women compared with HSV-1 seropositive women (pooled OR: 1.6; 95% CI: 0.6-4.0). The odds of neonatal HSV infection was increased in the presence of exposure to maternal HSV-1 versus HSV-2 (adjusted pooled OR: 19.2-3 95% CI: 5.8-63.6). An elevated odds of disseminated HSV in infants born to women with newly acquired genital herpes was observed in Stockholm (OR = 13.5; 95% CI: 1.4-630), but not in Seattle or Stanford. Conclusion. Our results suggest that maternal HSV-1 antibody offers little, if any, protection against neonatal HSV-2 infection. During reactivation, HSV-1 appears more readily transmissible to the neonate than HSV-2, a concerning finding given the rising frequency of genital HSV-1 infection.