MAGNETOENCEPHALOGRAPHY - THEORY, INSTRUMENTATION, AND APPLICATIONS TO NONINVASIVE STUDIES OF THE WORKING HUMAN BRAIN
MAGNETOENCEPHALOGRAPHY - THEORY, INSTRUMENTATION, AND APPLICATIONS TO NONINVASIVE STUDIES OF THE WORKING HUMAN BRAIN
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DOI：
10.1103/revmodphys.65.413
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发表时间：
1993-04-01
影响因子：
44.1
通讯作者：
LOUNASMAA, OV
中科院分区：
文献类型：
--
作者：
HAMALAINEN, M;HARI, R;LOUNASMAA, OV
磁脑摄影（MEG）是一种用于研究活人大脑中神经元活性的无创技术。该方法的时间分辨率优于1 ms，在有利的情况下，空间歧视是大脑皮层中的来源2-3 mm。在MEG研究中，用多通道鱿鱼（超导量子量子干扰装置）测量流动神经元的电流产生的弱10 FF-1 PT磁场。可以从检测到的磁场分布中找到被刺激激活的大脑皮层中的位点，前提是对源的适当假设使逆问题的解决方案具有独特的溶液。可以研究工作人脑的许多有趣特性，包括外部刺激后自发活动和信号处理。出于临床目的，确定癫痫病灶的位置是有意义的。作者从一般介绍和对MEG神经基础的简短讨论开始。然后将详细解释该方法的数学理论，然后对MEG仪器，数据分析和多块设备的实际结构进行详尽的描述。最后，描述了在作者实验室中进行的几项MEG实验，涵盖了诱发反应和健康和患病大脑中自发活动的研究。也简要讨论了其他小组的许多MEG研究。
Magnetoencephalography (MEG) is a noninvasive technique for investigating neuronal activity in the living human brain. The time resolution of the method is better than 1 ms and the spatial discrimination is, under favorable circumstances, 2-3 mm for sources in the cerebral cortex. In MEG studies, the weak 10 ff-1 pT magnetic fields produced by electric currents flowing in neurons are measured with multichannel SQUID (superconducting quantum interference device) gradiometers. The sites in the cerebral cortex that are activated by a stimulus can be found from the detected magnetic-field distribution, provided that appropriate assumptions about the source render the solution of the inverse problem unique. Many interesting properties of the working human brain can be studied, including spontaneous activity and signal processing following external stimuli. For clinical purposes, determination of the locations of epileptic foci is of interest. The authors begin with a general introduction and a short discussion of the neural basis of MEG. The mathematical theory of the method is then explained in detail, followed by a thorough description of MEG instrumentation, data analysis, and practical construction of multi-SQUID devices. Finally, several MEG experiments performed in the authors' laboratory are described, covering studies of evoked responses and of spontaneous activity in both healthy and diseased brains. Many MEG studies by other groups are discussed briefly as well.