A mouse model of foodborne Listeria monocytogenes infection.
A mouse model of foodborne Listeria monocytogenes infection.
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DOI：
10.1002/9780471729259.mc09b03s31
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发表时间：
2013-11-05
影响因子：
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通讯作者：
D'Orazio, Sarah E F
中科院分区：
文献类型：
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作者：
Bou Ghanem, Elsa N;Myers-Morales, Tanya;D'Orazio, Sarah E F
单核细胞增生李斯特菌引起人类食源性疾病，其严重程度从轻度自限性胃肠炎到危及生命的血液、大脑或胎盘全身感染不等。最常用的绦虫病动物模型是小鼠静脉内感染。该系统模型是高度可重复的，因此，对于研究针对细胞内细菌病原体的细胞介导的免疫应答是有用的，但它完全绕过了L.单核细胞增多症胃内接种L.单核细胞增多症产生更多的可变结果，并可能导致某些动物的直接血流侵入。这里描述的食源性传播模型不需要专门的技能来执行，并导致更接近人类疾病的感染。这种自然摄食模型可用于研究宿主和病原体来源的因素，这些因素决定了对口服获得性李斯特菌的易感性或抗性。单核细胞增多症
Listeria monocytogenes causes foodborne disease in humans that ranges in severity from mild, self-limiting gastroenteritis to life-threatening systemic infections of the blood, brain, or placenta. The most commonly used animal model of listeriosis is intravenous infection of mice. This systemic model is highly reproducible, and thus, useful for studying cell-mediated immune responses against an intracellular bacterial pathogen, but it completely bypasses the gastrointestinal phase of L. monocytogenes infection. Intragastric inoculation of L. monocytogenes produces more variable results and may cause direct bloodstream invasion in some animals. The foodborne transmission model described here does not require specialized skills to perform and results in infections that more closely mimic human disease. This natural feeding model can be used to study both the host- and pathogen-derived factors that govern susceptibility or resistance to orally acquired L. monocytogenes.