Particle dispersion and separation resolution of pinched flow fractionation
Particle dispersion and separation resolution of pinched flow fractionation
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DOI：
10.1021/ac0713813
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发表时间：
2008-03-01
影响因子：
7.4
通讯作者：
Posner, Jonathan D.
中科院分区：
文献类型：
--
作者：
Jain, Abhishek;Posner, Jonathan D.
本文研究了一种流体动力颗粒分离技术，该技术将颗粒夹持到狭窄的微通道中。颗粒受到突然膨胀的影响，这导致了横跨流动方向的基于尺寸的颗粒分离。用荧光显微镜测量了其分离分辨率和颗粒分散度。用紧凑的理论模型对分辨率和色散进行了预测。器件是使用传统的聚二甲基硅氧烷软光刻制造的。结果表明，分离分辨率是微通道长径比、颗粒大小差和微通道侧壁粗糙度的函数。本工作获得了高达3.8的分离分辨率。这项工作表明，直径在侧壁粗糙度数量级的颗粒不能用夹点流动分馏进行分离。
This paper investigates a hydrodynamic particle separation technique that employs pinching of particles to a narrow microchannel. The particles are subject to a sudden expansion which results in a size-based particle separation transverse to the flow direction. The separation resolution and particle dispersion are measured using epifluorescence microscopy. The resolution and dispersion are predicted using a compact theoretical model. Devices are fabricated using conventional soft lithography of polydimethylsiloxane. The results show that the separation resolution is a function of the microchannel aspect ratio, particle size difference, and the microchannel side-wall roughness. A separation resolution as large as 3.8 is obtained in this work. This work shows that particles with diameters on the order of the sidewall roughness cannot be separated using pinched flow fractionation.