Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique
Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique
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DOI：
10.1007/s00247-019-04384-7
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发表时间：
2019-06-01
影响因子：
2.3
通讯作者：
Wu, Holden H.
中科院分区：
文献类型：
--
作者：
Armstrong, Tess;Ly, Karrie, V;Wu, Holden H.
背景 身体成分和肝脂肪与未来代谢综合征的风险相关。对于儿童，许多量化身体成分和肝脂肪的传统技术都有局限性。 MRI 是一种无创研究工具，用于研究婴儿的身体成分和肝脂肪；然而，传统的笛卡尔 MRI 对运动敏感，特别是由于呼吸而在腹部运动。因此，我们开发了一种自由呼吸 MRI 技术来量化婴儿的身体成分和肝脂肪。 目的 对于婴儿，我们的目标是 (1) 比较肝脏中自由呼吸 3D 径向堆栈 MRI（自由呼吸径向）和 3D 笛卡尔 MRI 之间的图像质量，以及 (2) 确定使用自由呼吸径向 MRI 来量化身体成分和肝脏质子密度脂肪分数的可行性(PDFF). 材料和方法 对 10 名 2-7 个月大的婴儿进行自由呼吸径向（两名腹部；一名头部和胸部）和笛卡尔（一名腹部）MRI 序列扫描。报告了中位准备时间和扫描时间。为了评估肝脏 PDFF 量化的可行性，放射科医生在接受 MRI 技术的情况下，使用 3 分制（1 或非诊断性，3 或无伪影）对肝脏运动伪影的腹部扫描进行评分。使用自由呼吸径向 MRI 测量中位内脏脂肪组织 (VAT)、皮下脂肪组织 (SAT) 和棕色脂肪组织 (BAT) 体积以及 PDFF 和肝脏 PDFF。我们评估了连续扫描之间自由呼吸径向肝 PDFF（重复性系数）的可重复性。我们使用 McNemar-Bowker 测试确定了图像质量分数分布的差异。磷
Background Body composition and hepatic fat correlate with future risk for metabolic syndrome. In children, many conventional techniques for quantifying body composition and hepatic fat have limitations. MRI is a noninvasive research tool to study body composition and hepatic fat in infants; however, conventional Cartesian MRI is sensitive to motion, particularly in the abdomen because of respiration. Therefore we developed a free-breathing MRI technique to quantify body composition and hepatic fat in infants.Objective In infants, we aimed to (1) compare the image quality between free-breathing 3-D stack-of-radial MRI (free-breathing radial) and 3-D Cartesian MRI in the liver and (2) determine the feasibility of using free-breathing radial MRI to quantify body composition and hepatic proton-density fat fraction (PDFF).Materials and methods Ten infants ages 2-7 months were scanned with free-breathing radial (two abdominal; one head and chest) and Cartesian (one abdominal) MRI sequences. The median preparation and scan times were reported. To assess feasibility for hepatic PDFF quantification, a radiologist masked to the MRI technique scored abdominal scans for motion artifacts in the liver using a 3-point scale (1, or non-diagnostic, to 3, or no artifacts). Median visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and brown adipose tissue (BAT) volume and PDFF, and hepatic PDFF were measured using free-breathing radial MRI. We assessed repeatability of free-breathing radial hepatic PDFF (coefficient of repeatability) between back-to-back scans. We determined differences in the distribution of image-quality scores using McNemar-Bowker tests. P