Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues.
Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues.
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DOI：
10.1021/acs.nanolett.3c02263
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发表时间：
2023-09
期刊：
影响因子：
10.8
通讯作者：
Sepideh Afsari;Sohini Mukherjee;Nicholas Halloran;Giovanna Ghirlanda;Eathen O Ryan;Xu Wang;S. Lindsay
中科院分区：
文献类型：
--
作者：
Sepideh Afsari;Sohini Mukherjee;Nicholas Halloran;Giovanna Ghirlanda;Eathen O Ryan;Xu Wang;S. Lindsay
蛋白质是多功能的、自组装的纳米电子元件，但它们的跳跃导电性预计会受到溶剂波动的影响。通过测量几种蛋白质在H2O和D2O中的单分子电导，研究了溶剂的作用。在D2O中，一系列同源蛋白质的电导随着长度的增加而下降得更快，这表明相对于相同的蛋白质在H2O中，载流子扩散常数减小了6倍。研究发现，这种作用依赖于特定的芳香氨基酸组成。色氨酸拉链蛋白表现出与蛋白丝相似的电导下降，而苯丙氨酸拉链蛋白对溶剂变化不敏感。色氨酸含有吲哚胺，而苯丙氨酸芳环没有可交换的质子，因此重水对电导的影响是特定的D-或H-与芳香族残基相互作用的结果。
Proteins are versatile, self-assembling nanoelectronic components, but their hopping conductivity is expected to be influenced by solvent fluctuations. The role of the solvent was investigated by measuring the single molecule conductance of several proteins in both H2O and D2O. The conductance of a homologous series of protein wires decreases more rapidly with length in D2O, indicating a 6-fold decrease in carrier diffusion constant relative to the same protein in H2O. The effect was found to depend on the specific aromatic amino acid composition. A tryptophan zipper protein showed a decrease in conductance similar to that of the protein wires, whereas a phenylalanine zipper protein was insensitive to solvent changes. Tryptophan contains an indole amine, whereas the phenylalanine aromatic ring has no exchangeable protons, so the effect of heavy water on conductance is a consequence of specific D- or H-interactions with the aromatic residues.