Construction of atorvastatin dose-response relationships using data from a large population-based DNA biobank
Construction of atorvastatin dose-response relationships using data from a large population-based DNA biobank
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DOI：
10.1111/j.1742-7843.2006.00035.x
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发表时间：
2007-04-01
影响因子：
3.1
通讯作者：
Wilke, Russell A.
中科院分区：
文献类型：
--
作者：
Peissig, Peggy;Sirohi, Ekta;Wilke, Russell A.
方法.本研究已获得Marshfield Clinic机构审查委员会的事先批准。本研究按照《赫尔辛基宣言》的基本原则进行。该设计代表了一项回顾性观察性研究，使用来自Marshfield Clinic PMRP数据库的100名参与者的测试样本。目前，PMRP数据库包含19 000多名参与者的编码电子医疗记录。绝大多数人通过马什菲尔德诊所接受医疗保健，这是一个位于威斯康星州中部的横向整合的多专业团体实践。这个社区的迁入和迁出率都很低。对于居住在与马什菲尔德诊所相关的邮政编码的患者，电子病历捕获了所有门诊就诊的95%和所有住院就诊的93%。由于Marshfield Clinic十多年来一直保持这种高度集成的病历，因此从病历转移到PMRP数据库的所有临床数据都可以进行电子摘要（即通过使用文本挖掘算法进行可编程审查）。对于当前研究，选择了老年研究人员的测试集，因为他们通常具有与降脂治疗相关的较高频率的临床状况[5]。通过使用年龄和诊断代码的初始数据询问策略，在PMRP数据库中确定了老年人的样本队列。为了避免对晚期认知障碍患者使用他汀类降脂治疗的潜在提供者偏倚，本研究未纳入既往诊断为痴呆的PMRP受试者。最初的电子搜索策略产生了336名年龄在80岁及以上的独特PMRP参与者，没有痴呆的基础诊断。从这个预先选定的PMRP参与者组中，选择了100个独特的人作为进一步研究的样本。
Methods. This study received prior approval from the Marshfield Clinic Institutional Review Board. The study was conducted in accordance with the basic Principles of the Declaration of Helsinki. The design represents a retrospective observational study utilizing a test sample of 100 participants from the Marshfield Clinic PMRP database. At present, the PMRP database contains coded electronic medical records for more than 19,000 participants. The large majority receive their health care through Marshfield Clinic, a horizontally integrated, multi-specialty group practice located in central Wisconsin. This community exhibits very low inand out-migration rates. For patients residing in ZIP codes associated with Marshfield Clinic, the electronic medical record captures 95% of all outpatient encounters and 93% of all inpatient encounters. Because Marshfield Clinic has maintained this highly integrated medical record for over a decade, all clinical data moved into the PMRP database from medical records is amenable to electronic abstraction (ie programmable review through the use of text-mining algorithms).For the current study, a test set of older study persons was selected because they typically have a higher frequency of clinical conditions associated with lipid lowering therapy [5]. A sample cohort of older people was identified within the PMRP database through an initial data interrogation strategy that used age and diagnostic codes. In order to avoid a potential provider-bias against the use of statin-based lipid lowering therapy in patients with advanced cognitive impairment, PMRP participants with a prior diagnosis of dementia were not included in the current study. The initial electronic search strategy yielded 336 unique PMRP participants aged 80 years and older with no underlying diagnosis of dementia. From this pre-selected group of PMRP participants, a sample of 100 unique persons was selected for further study.