Modelling propagation and re-entry in anisotropic and smoothly heterogeneous cardiac tissue

Modelling propagation and re-entry in anisotropic and smoothly heterogeneous cardiac tissue
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模拟各向异性和平滑异质心脏组织中的传播和重新进入

DOI:
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发表时间:
1993
期刊:
影响因子:
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通讯作者:
Henggui Zhang
Henggui Zhang
中科院分区:
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文献类型:
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作者:
A. Holden;Henggui Zhang

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心肌是由一个简单的、三维的、耦合的映射格子和分量映射来模拟的,这些映射显示了动作电位时程中适当的速率依赖的变化。传导速度的各向异性和动作电位持续时间的不均一性是由控制MAP和动作电位持续时间之间耦合的参数沿模型的一个参数的一个轴的均匀空间梯度产生的。在与组织细丝垂直的方向上的耦合参数和在平行于组织细丝的方向上控制动作电位持续时间的参数的不均匀导致涡旋波的变形和随后的破裂,从而产生新的相互作用的漩涡。
Cardiac muscle is modelled by a simple, three-dimensional, coupled map lattice with component maps that show appropriate rate-dependent changes in action-potential duration. Anisotropy of conduction velocity and heterogeneity of action-potential duration is produced by a uniform spatial gradient along one axis of one parameter of the model, for parameters that control the coupling between maps and the action-potential duration. Non-uniformity of the coupling parameter in a direction orthogonal to the organising filament and of the parameter controlling the action-potential duration in a direction parallel to the organising filament gives rise to distortion and then breakdown of the scroll wave, producing new, interacting vortices.
DOI: 10.1161/01.res.72.3.631
发表时间: 1993-03-01
影响因子: 20.1
作者:
PERTSOV, AM;DAVIDENKO, JM;JALIFE, J
通讯作者: JALIFE, J