Analysis of amphetamine, methamphetamine and methylenedioxy‐methamphetamine by micellar capillary electrophoresis using cation‐selective exhaustive injection
Analysis of amphetamine, methamphetamine and methylenedioxy‐methamphetamine by micellar capillary electrophoresis using cation‐selective exhaustive injection
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使用阳离子选择性彻底进样，通过胶束毛细管电泳分析苯丙胺、甲基苯丙胺和亚甲二氧基甲基苯丙胺
DOI：
10.1002/elps.200500886
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发表时间：
2006
期刊：
影响因子：
2.9
通讯作者：
D. Chen
中科院分区：
文献类型：
--
作者：
P. Meng;Ning Fang;Meng Wang;Huwei Liu;D. Chen
Cation‐selective exhaustive injection (CSEI) is used as an on‐line concentration method for the high‐sensitivity analysis of illicit amphetamines using CE. Optimum conditions for the determination of amphetamine, methamphetamine and methylenedioxy‐methamphetamine were investigated. Sodium dodecyl sulfate (25 mM) in 100 mM phosphate buffer (pH 2.9) with 20% methanol as organic additive was used as the background electrolyte for CE separation. The LOD, based on an S/N of 3:1, was about 0.01 μg/mL using normal capillary micellar electrokinetic chromatography, while by using CSEI in combination with micellar sweeping the sensitivity increased up to 1000‐fold with the LOD lower than 50 pg/mL. The reproducibility of CSEI combined with micellar sweeping for analyzing amphetamines was satisfactory (relative standard deviation around 10% by using area ratios against an internal standard). This method is highly sensitive and can be used to analyze trace amount amphetamines in human hair.
