Genetic Relations Between Effortful and Attentional Control and Symptoms of Psychopathology in Middle Childhood.
Genetic Relations Between Effortful and Attentional Control and Symptoms of Psychopathology in Middle Childhood.
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努力和注意力控制与童年中期精神病理学症状之间的遗传关系。
DOI：
10.1002/icd.581
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发表时间：
2008-08
影响因子：
2.2
通讯作者：
Goldsmith HH
中科院分区：
文献类型：
--
作者：
Lemery-Chalfant K;Doelger L;Goldsmith HH
本文的重点是阐明努力控制（母亲和父亲在两个时间点的报告），注意力控制（观察员报告）及其与内化和外化症状（母亲和父亲报告）的关联的遗传和环境病因。以参加威斯康星州双胞胎项目的儿童中期双胞胎为样本，父母报告的努力控制的广义遗传力范围为68- 79%，观察者报告的注意力控制的遗传力估计值略高，为83%，共享环境对这两种特质都没有影响。此外，控制措施呈负相关，内在和外在症状纵向，同时，跨记者。重要的是，共享的加性遗传影响占控制变量和精神病理学症状之间的协变。这些结果鼓励识别影响努力控制和症状的共同基因，以及独特影响精神病理学症状的环境触发因素。
Elucidating the genetic and environmental etiology of effortful control (mother and father report at two time points), attentional control (observer reports) and their associations with internalizing and externalizing symptoms (mother and father report) is the central focus of this paper. With a sample of twins in middle childhood participating in the Wisconsin Twin Project, broad sense heritability for parental report effortful control ranged from 68–79%, with a slightly higher heritability estimate of 83% for observer report attentional control, and no influence of the shared environment on either trait. Further, measures of control were negatively correlated with internalizing and externalizing symptoms longitudinally, concurrently, and across reporters. Importantly, shared additive genetic influence accounted for the covariation between the control variables and symptoms of psychopathology. These results encourage identification of common genes that affect both effortful control and symptoms, and environmental triggers that uniquely influence symptoms of psychopathology.